Ivermectin for the Prevention or Treatment of COVID-19

During the COVID-19 pandemic, ivermectin has been one of the most controversial drugs despite an enormously positive body of evidence.

Educational Content

The Ivermectin Story with a forward by Dr. Pierre Kory of the FLCCC.1)

Pierre Kory (again!) with a timely update on the whole ivermectin picture, published on January 6, 2022.2)


  • Probable mechanisms of action of ivermectin against SARS-CoV-2.3)
  • Review which compiles all the molecular evidence to date, discusses Ivermectin's mechanism of action, and highlights the clinical advantages that could potentially contribute towards disabling the viral replication of SARS-CoV-2.

by Zheng Yao Low, et. al.
posted October 20, 2021 in the journal BBA Molecular Basis of Disease
Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication


Ivermectin Evidence Research on COVID-19 Efficacy

Prophylaxis Research

October 28, 2021: 'Ivermectin Prophylaxis Survey of 306 Health Care Workers in India' by Ajay Kumar Verma et. al., published in the Indian Journal of Community Health 4)

January 15, 2022: 'Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching' Kerr L, Cadegiani F A, Baldi F, et al. (January 15, 2022) Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching. Cureus 14(1): e21272. doi:10.7759/cureus.212725)

“When adjusted for residual variables, reduction in mortality rate was 70%. After adjustment for residual variables, reduction in hospitalization rate was 67%.

Conclusion: In this large PSM study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.”

Therapeutic Research

Retrospective analysis of 92 severe Covid-19 patients by Dr. Jackie Stone et. al., pre-print posted on 09 Nov, 2021.6)

Meta-Analyses of Ivermectin Efficacy

A meta-analysis published by Roman et al in the journal Clinical Infectious Diseases was met with heavy scrutiny by statistician Mathew Crawford and others.

  • A Bayesian re-analysis of the evidence presented in the Bryant and Roman papers, written by Martin Neil and Norman Fenton, and published in a Letter to the Editor in the American Journal of Therapeutics, suggested that the included evidence demonstrated a likelihood of efficacy: “Taking this into account, there is clearly an effective RR and RD in support of ivermectin in the severe case: The probability of the RR being less than one is 90.7%. The case for ivermectin mortality improvement in mild/moderate cases is less clear: The probability of the RR being less than one is 84.1%, but it is more survivable in this case and there are fewer “events” to learn from.”

Empirical Medicine

Many physicians around the world have used ivermectin as a prophylaxis or treatment for COVID-19 patients. • Dr. Peter McCullough • Dr. Brian Tyson • Dr. Ira Bernstein • Dr. Richard Urso • Dr. Ryan Cole • Dr. Shankara Chetty • Dr. George Fareed • Dr. Pierre Kory • Dr. Paul Marik

Critiques of Ivermectin Research

Experts Debate

National and Regional Stories


Tainted Science

Tess Lawrie and Andrew Hill

Propaganda Campaign

As ivermectin became a popular medicine used to treat COVID-19 patients, many mainstream media outlets run rhetorically damning stories. The purpose of these stories seems to be to justify withholding the medication, or even censuring physicians using it to treat patients. The following articles may or may not intentionally be part of the a propaganda campaign. The authors could simply be morons, which is not terribly uncommon in “science journalism”.

Hospitals Refusing Treatment

Court Cases

Many hospitals have issued new administrative policies which restrict doctors from prescribing ivermectin to treat patients with Covid-19. Upon refusal, many patients have resorted to filing lawsuits against hospitals to receive the treatment. Below is a list of these court cases:

Attorney Ralph Lorigo represented many of the plaintiffs in these cases.

Participation by Regulatory Agencies

FDA/Woodcock and NYT caught lying about ivermectin https://rescue.substack.com/p/a2520b80-bcd1-4905-a913-68f6f6809779


IVM doc in Alberta, Canada https://patriots.win/p/13zg4u10La/doctor-sneaks-ivermectin-into-ho/


Ivermectin inhibits SARS CoV-2 replication



IVM targets NS3 helicase

John Campbell talks about mechanisms of ivermectin (includes many links to papers which should be pulled in here): Intro video on Mechanisms of ivermectin

Ivermectin Safety Data

A meta-analysis in the Journal of Anti-microbial Chemotherapy examined the safety of high dose ivermectin and concluded safety of ivermectin in high doses seems to be comparable to that of lower doses. https://academic.oup.com/jac/article/75/4/827/5710696

Ivermectin is on the WHO list of essential medicines: https://www.who.int/publications/i/item/eml-20

Safety of doses up to 10 times the highest FDA approved dose of 200 µg/kg have been well tolerated. https://pubmed.ncbi.nlm.nih.gov/12362927/

Adverse events are typically non-severe if they occur: https://europepmc.org/article/PMC/PMC2491300 https://pubmed.ncbi.nlm.nih.gov/14975060/

MedinCell publishes an extensive Ivermectin safety expert analysis. Press release: https://www.businesswire.com/news/home/20210305005353/en/Covid-19-MedinCell-Publishes-an-Extensive-Ivermectin-Safety-Expert-Analysis (Download review: https://www.medincell.com/ivermectin)

Ivermectin has proven it's application for a wide-range of diseases: https://www.cell.com/trends/parasitology/fulltext/S1471-4922(14)00126-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471492214001263%3Fshowall%3Dtrue https://www.nature.com/articles/ja201711

Medications can be prescribed off-label and ivermectin is no different. Rationale for prescribing ivermectin off-label during a pandemic:

10% to 20% of all prescriptions are prescribed off label https://pubmed.ncbi.nlm.nih.gov/24444499/

A Cochrane review from 2014 concluded “there is little evidence for significant effect estimate differences between observational studies and RCTs.” https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.MR000034.pub2/full

31% of clinical practice guidelines for infectious diseases are currently formed using observational studies: https://academic.oup.com/cid/article/51/10/1147/392207

On October 14, 2021, the State of Nebraska issued a statement: “Allowing physicians to consider these early treatments will free them to evaluate additional tools that could save lives, keep patients out of the hospital, and provide relief for our already strained heathcare system.“ Concluding, physicians should be allowed “to prescribe ivermectin or hydroxychloroquine to prevent or treat COVID-19.” https://ago.nebraska.gov/opinions/prescription-ivermectin-or-hydroxychloroquine-label-medicines-prevention-or-treatment-covid

Mary Beth Pfieffer (@marybethpf). September 22, 2021. Louisiana Attorney General said he supports ivermectin prescriptions. In a 9/7 letter to LA pharmacy board, @AGJeffLandry wrote, “I find nothing that would allow the Board to second guess the sound medical judgment of a physician when it comes to prescribing legal drugs..” https://twitter.com/marybethpf/status/1440586447925350404?s=20

NIH COVID-19 Treatment Guidelines. Table 2e. Characteristics of Antiviral Agents That Are Approved or Under Evaluation for the Treatment of COVID-19. Last Updated July 8, 2021. https://www.covid19treatmentguidelines.nih.gov/tables/table-2e/

World Council for Health. September 30, 2021. Early Covid-19 treatment guidelines: A practical approach to home-based care for healthy families. https://worldcouncilforhealth.org/resources/early-covid-19-treatment-guidelines-a-practical-approach-to-home-based-care-for-healthy-families/

Ivermectin in the news:

GNews. Greenlight for ivermectin. August 18, 2021. https://gnews.org/1476750/

The BIRD Group. Dr Tess Lawrie speaks about ivermectin and the authorities. August 16, 2021. https://bird-group.org/dr-tess-lawrie-speaks-about-ivermectin-and-the-authorities/

The Desert Review. Imperial Valley news that matters to you. The great Ivermectin deworming hoax. Updated September 8, 2021. https://www.thedesertreview.com/opinion/columnists/the-great-ivermectin-deworming-hoax/article_19b8f2a6-0f29-11ec-94c1-4725bf4978c6.html

YourObserver.com. The battle for ivermectin. August 18, 2021. (Click on the page to read the full article.) https://www.yourobserver.com/article/the-battle-for-ivermectin

Alexandros Marinos rebuttal to Scott Alexander piece: https://doyourownresearch.substack.com/p/a-conflict-of-blurred-visions?showWelcome=true

Australia Removal of prescribing restrictions on ivermectin https://www.tga.gov.au/news/media-releases/removal-prescribing-restrictions-ivermectin

Back to top