Discovery of Medical Countermeasures Against Novel Entities

Discovery of Medical Countermeasures Against Novel Entities (DOMANE) is a program of the Defense Threat Reduction Agency (DTRA) intended to rapidly identify drugs and compounds for repurposing against emerging pathogens.¹⁾

DOMANE was created in 2019.²⁾ On December 11, 2019, the DTRA published a whitepaper outlining the project.³⁾

In early 2020, Michael Callahan alerted his colleague Robert Malone, then working as chief medical officer at Alchem Laboratories, of the emerging SARS-CoV-2 outbreak in Wuhan, China. Malone was also working on the DOMANE project, which identified several drugs approved by the Food and Drug Administration (FDA) that may work as potential treatments against COVID-19, the disease thought to result from infection with the virus.⁴⁾

One of the first drugs identified was remdesivir, an experimental product developed by Gilead Sciences for use against Ebola.⁵⁾

Another candidate for repurposing was famotidine, an anti-heartburn drug marketed in the United States by Johnson & Johnson as Pepcid.^{6) 7)} On April 14, the Biomedical Advanced Research and Development Authority (BARDA) awarded Alchem a $20.7 million contract the conduct a clinical trial on the drug.

Other drugs identified were Celecoxib, a drug sold by Pfizer under the name Celebrex to treat arthritis, and Mectizan, Merck's brand of ivermectin.⁸⁾

DTRA also partnered with Quantum Leap Healthcare and Leidos to conduct clinical trials on various combinations of the repurposed drugs.

According to Vanity Fair, the DOMANE team made contact with White House physician Sean Conley in regards to the protocol used to treat President Donald Trump when he was diagnosed with COVID-19.⁹⁾

DOMANE was featured in the January 2021 issue of JSTO in the News, in which the program was described as using the COVID-19 pandemic as a “proof-of-concept” for future use in biodefense.¹⁰⁾ It describes the use of “virtual clinical trials” involving wearables, telehealth, “e-consent”, and electronic storage of patient information.

Substack - Puppet Masters of the Pandemic. Part 1: What Did The CIA Do in Wuhan?“ Part 1 of an interview with the New American Magazine Robert W Malone MD, MS - Aug 3, 2023

By the way, the whole storyline that I was in charge of programs at DTRA is laughable. I was a small subcontractor with a DoD secret clearance. There's no way that a subcontractor would be given a programmatic authority over major biodefense programs such as DOMANE. So that's a whole false storyline that's been developed and repeatedly amplified by some of my detractors.

And yes, DOMANE did take credit for the development of Remdesivir because of what DTRA had done during the Ebola outbreak, working together with Michael Callahan. ¹¹⁾

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