COVID-19

Coronavirus disease 2019 or COVID-19 is a disease first associated with some people infected with the SARS-CoV-2 virus and later associated with some recipients of the COVID-19 vaccines.

A COVID-19 case has often been confused with a SARS-CoV-2 infection. However, viral infection has not historically implied disease. This has created substantial confusion, and made statistics harder to gather and evaluate.

COVID-19 is primarily associated with acute respiratory syndrome, gastrointestinal, and vascular problems. However, SARS-CoV-2 can cause problems in nearly every organ.¹⁾ Inflammation and organ failure lead to much of the most severe damage in COVID-19 patients.

The physical phenotypes of blood cells (erythrocytes, lymptocytes, monocytes, and neutrophils) are altered in COVID-19, with some effects remaining after hospital release.²⁾

Some research points toward SARS-CoV-2 endothelial entry via integrin pathways, eliciting vascular leakage events.³⁾

On September 3, 2021, the CDC published a study purporting to show that COVID-19 is associated with a 16-fold higher risk of myocarditis.⁴⁾

Sometimes COVID-19 results in complications in the gastrointestinal system. These can include nausea, vomiting, and diarrhea, but also bile duct casts and cholangitis in some cases.⁵⁾

The bile tract plays a role in interleukin-8 cytokin storming.

Post-acute coronavirus disease 2019 syndrome (PACS), also known as “long haul COVID”, plagues a significant fraction (around one-third) of those who develop COVID-19 suffer long-term health consequences after recover from the acute form of the disease.⁶⁾ Long haul symptoms can last for many months.⁷⁾

The most common sequelae of those suffering long haul COVID symptoms include fatigue, post-external malaise, brain fog, select sensorimotor symptoms, headaches and related symptoms, memory issues, insomnia, and muscle aches.⁸⁾ In some cases, long haul COVID has been associated with reactivation of neurotrophic pathogens such as herpesvirus.⁹⁾

A small number of affected children suffer from pediatric inflammatory multisystem syndrome that is temporally associated with SARS-CoV-2 infection (PIMS-TS).¹⁰⁾

Immunoglobulin (Ig) singnature has been associated with long haul COVID, as well as age, asthma bronchiale, and some symptoms during primary infection.¹¹⁾

• February 10, 2022 - Targeting the Monocytic-Endothelial-Platelet Axis with Maraviroc and Pravastatin as a Therapeutic Option to Treat Long COVID/ Post-Acute Sequelae of COVID (PASC)¹²⁾

We usually do not talk about an asymptomatic disease state in medicine, though it is debatably more plausible that COVID-19 is associated with increased health problems not detectable by early outward symptoms.

COVID-19 is a complex disease that potentially affects different systems all over the body.

A summary of risk factors can be summarized as, “COVID-19 affects people in proportion to the weaknesses in their immune system,” whether generally correlated with age or with other comorbidities such as nutrient deficiencies or diseases of the immune system including diabetes.¹³⁾

Research associates COVID-19 cases and severity with deficiencies in numerous vitamins and minerals. Colleen Huber, NMD declares COVID-19 to be a “lack of nutrients, exploited by a virus,” but is somewhat vague on the mechanistic details. ¹⁴⁾ Each of these may or may not relate to other system aspects of disease covered in this article.

• Age
• Body Mass Index
• Diabetes
• Fatigue and Poor Sleep
• Immunodeficiency
• Mental Illness/Learning Disabilities
• Race/Ethnicity
• Vitamin and Mineral Deficiencies
• Other Correlates of Interest

The COVID-19 age curve is steep, with the elderly effected most and the young effected the least.¹⁵⁾ The more severe the case of COVID, the steeper is the age curve.

Seealso : Risk Stratification

Autoimmune disorders and immunodeficiency might be described as the “primary COVID-19 correlate and comorbidity”, but is strangely underdiscussed by public health officials and the mainstream media.

There is conflicting discussion of a correlation between COVID-19 and blood type, but evidence of a link may have thinned over time.

• MedpageToday)
• WebMD: Blood type doesn't affect your COVID Risk

• Shimizu et al (Dec 2, 2021): Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2.
• * Gene associated with less severe COVID more common in Asia.
• * The Washington Free Beacon, Nov 29, 2021: Discussing this research is racist.

Tepasse et al, 2021 showed significant association between Vitamin A and many endpoints of disease progression such as hospitalization, ARDS, and mortality.¹⁶⁾

• https://agingbiotech.info/vitamindcovid19/

• https://agingbiotech.info/vitamindcovid19facts/1pager.pdf

COVID-19 has been observed in some research to increase odds ratios of mortality the most with those suffering from diabetes (6.426), renal failure (4.338), and hypertension (3.261). ¹⁷⁾

https://pubmed.ncbi.nlm.nih.gov/34779496/

https://pubmed.ncbi.nlm.nih.gov/34485092/

There is some evidence that prion-like domains in the spike protein enable higher affinity for ACE2 receptor binding. https://www.youtube.com/watch?v=fNFzfwLM72c&t=2s

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7988450/

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