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Spike Protein

What is a spike protein. Function of spike protein. Spike in other coronaviruses. Discuss past implications of spike in pathologies.

SARS-CoV-2 Spike Protein

Mention ACE2 affinity relative to SARS spike protein. Specific characteristics including those which point to a lab origin. Specific and detail ACE2 binding information.

Explain spike protein as a target for antibodies and value in vaccine manufacturing.

Proposed Mechanisms of SARS-CoV-2 Spike Protein Pathology

Detail effects of ACE2 down-regulation and subsequent impact on RAAS. Detail role of Angiotensin 2 in inflammation, clotting, angiogenesis, etc.

AGE/RAGE connection with Ang 2 pathology.

“In addition to eliciting an immune response that suppresses the viral entry, the spike protein produced by the COVID-19 vaccines may also affect the host cells, possibly triggering adverse events.1)

Spike Protein SARS-CoV-2

A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination William J. Murphy, Ph.D., and Dan L. Longo, M.D.

https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694

Spike protein clotting

https://www.biorxiv.org/content/10.1101/2021.10.12.464152v1

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice: https://pubmed.ncbi.nlm.nih.gov/33328624/

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier: https://pubmed.ncbi.nlm.nih.gov/33053430/

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease: https://www.biorxiv.org/content/10.1101/2020.12.21.423721v2.full.pdf

Clearing up misinformation about the spike protein and COVID vaccines: https://joomi.substack.com/p/coming-soon

1)
Suzuki, Y. J., & Gychka, S. G. (2021). SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines, 9(1), 36. https://doi.org/10.3390/vaccines9010036
spike_protein.txt · Last modified: 2021/12/24 03:10 by joomi