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Spike Protein
What is a spike protein. Function of spike protein. Spike in other coronaviruses. Discuss past implications of spike in pathologies.
SARS-CoV-2 Spike Protein
Mention ACE2 affinity relative to SARS spike protein. Specific characteristics including those which point to a lab origin. Specific and detail ACE2 binding information.
Explain spike protein as a target for antibodies and value in vaccine manufacturing.
Proposed Mechanisms of SARS-CoV-2 Spike Protein Pathology
Detail effects of ACE2 down-regulation and subsequent impact on RAAS. Detail role of Angiotensin 2 in inflammation, clotting, angiogenesis, etc.
AGE/RAGE connection with Ang 2 pathology.
“In addition to eliciting an immune response that suppresses the viral entry, the spike protein produced by the COVID-19 vaccines may also affect the host cells, possibly triggering adverse events.1)
Spike Protein SARS-CoV-2
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination William J. Murphy, Ph.D., and Dan L. Longo, M.D.
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Spike protein clotting
1)
Suzuki, Y. J., & Gychka, S. G. (2021). SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines, 9(1), 36. https://doi.org/10.3390/vaccines9010036