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SARS-CoV-2 Spike Protein
The SARS-CoV-2 spike glycoprotein stands out as unique.
Potential Pathological Mechanisms of Anti-Spike Antibodies
- The Spike Protein As a Pore-Forming Toxin1)
Blood Clotting
- SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy2)
Cancer Pathway
There is evidence that the S2 subunit of SARS-CoV-2 interacts with P53, the tumor suppressor protein whose pathway is associated with most or all human cancer, and BRCA, in an in silico study.3)
Pathogenic Antibodies
- Pathogenic antibodies induced by spike proteins of COVID-19 and SARS-CoV viruses4)
Genetic Damage
- SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro5)
Links to Sort
The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA https://pubmed.ncbi.nlm.nih.gov/34204305/
1)
March 19, 2022 | Chris Masterjohn | The Spike Protein As a Pore-Forming Toxin
2)
October 13, 2021 | Jae Kyu Ryu et al | preprint | SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy | doi: https://doi.org/10.1101/2021.10.12.464152
3)
June 30, 2020 | Nishant Singh and Anuradha Singh | Transl Oncol (Journal) | S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study | doi: 10.1016/j.tranon.2020.100814
4)
June 16, 2021 | Huiru Wang et al | preprint | Pathogenic antibodies induced by spike proteins of COVID-19 and SARS-CoV viruses | DOI: https://doi.org/10.21203/rs.3.rs-612103/v2
5)
October 13, 2021 | Hui Jiang and Ya-Fang Mei | SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro | DOI: 10.3390/v13102056