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The Vaccine Wars
Risk-Benefit Analysis
Vaccine Risks
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- Side effects/Adverse events
- Disinfectants
- Antibody-dependent enhancement (ADE)
- Dependence
- Lack of Impact/Efficacy
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- Nanoparticle Toxicity
- Societal (in)stability
- Enhancement and (immune) escape
- Biological surveillance and manipulation
- The unknown unknowns
Defining Away Vaccine Safety Signals
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- The CDC's safety signal analysis uses inappropriate tools (proportional reporting analysis or PRR) only, without respect to magnitudes of events at all.
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- Historically, pharmacovigilance uses may tools aside from PRR.
- Discussed critiques
- Showed example of high harms not triggering safety signals used by CDC.
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- Vaccine Safety Datalink (VSD) uses the same flawed PRR metrics.
- PRR is known in the literature to “mask” safety signals in sitautions in which two therapeutics have similar adverse event profiles.