Medical doctors, both clinicians and researchers, document and share their research by publishing it in medical journals. Typically the papers undergo a process of editorial review and peer review prior to publication. The papers can cover a wide variety of topics and types of research including controlled clinical trials, observational studies, case reports, laboratory research results, clinical research, pilot studies, feasibility studies, cohort studies, case control studies, cross sectional studies, in silico experiments, correspondence, and editorials.

EUA for PCR Tests Withdrawn

"After December 31, 2021, CDC will withdraw the request to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel, the assay first introduced in February 2020 for detection of SARS-CoV-2 only. CDC is providing this advance notice for clinical laboratories to have adequate time to select and implement one of the many FDA-authorized alternatives."

Naturally Acquired Immunity

136 Research Studies (and counting!) Affirm Naturally Acquired Immunity to Covid-19.

From Israel, mid-July 2021, nearly 40% of new COVID patients were vaccinated - compared to just 1% who had been infected previously.

Early Treatment & Therapeutics

This Covid-19 therapeutics tracker will be updated biweekly with the latest in developments for treatment candidates who have advanced to at least Phase 1 study.

The WHO therapeutics page.

The NIH therapeutic treatment recommendations.

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence

Synergistic Anti-SARS-CoV-2 Activity of Repurposed Anti-Parasitic Drug Combinations

Covid Interventions - Questions & Failures

A collection of over 400 studies on the failure of Covid interventions.

Leveraging epidemiological principles to evaluate Sweden’s COVID-19 response

Calling for benefit–risk evaluations of COVID-19 control measures

Dangerous pathogens found on children’s face masks (though they did only test six masks...)

A risk-benefit analysis of masks for children.

Heart-Related Issues with the Vaccines

France advises against Moderna for under-30s over rare heart risk.

Myocarditis and Pericarditis After mRNA COVID-19 Vaccination, from the CDC.

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

The Impact of Anti-Depressants

Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort

Association between SSRI Antidepressant Use and Reduced Risk of Intubation or Death in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study

Risk of Hospitalization, severe disease, and mortality due to COVID-19

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany

Vaccine Development & Approval

An Overview Of Vaccine Development, Approval, And Regulation, With Implications For COVID-19

The Pfizer science, as presented to the FDA in December 2020.

Vaccinating Children

Covid-19 vaccines for children: hypothetical benefits to adults do not outweigh risks to children

Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-Württemberg, Germany

Children are unlikely to be the main drivers of the COVID-19 pandemic - A systematic review

Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study

Why are we vaccinating children against COVID-19?

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany

Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States

The UK's vaccine advisory body has refused to give the green light to vaccinating healthy children aged 12-15 years on health grounds alone. This was in September. Ten days later, they reversed their position!

Vaccine Passports

COVID-19 immunity passports and vaccination certificates: scientific, equitable, and legal challenges

Vaccine Safety & Effectiveness

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19.

SARS-CoV-2 prion-like domains in spike proteins enable higher affinity to ACE2 (not peer reviewed).

Latest statistics (December 2021) on England mortality data suggest systematic mis-categorisation of vaccine status and uncertain effectiveness of Covid-19 vaccination.

An investigation into the transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community.

Covid-19 Vaccine Effectiveness in New York State

Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam.

Short term efficacy and safety data for the Pfizer vaccine, prepared by Physicians for Informed Consent.

Real world efficacy of Covid-19 vaccines.

Analysis of COVID-19 vaccine death reports from the Vaccine Adverse Events Reporting System (VAERS) Database Interim: Results and Analysis.

Vaccines Suspended or Withdrawn

Sweden, Norway, and Finland suspend use of Moderna vaccine in young people “as a precaution”. And here is the CDC's take on the same story, from October 2021.

France advises against Moderna for under-30s over rare heart risk.

Back in March 2021, Canada suspends use of AstraZeneca Covid vaccine for those under 55 and then, less than a month later, relaxes age limits on AstraZeneca vaccine as Ontario cases surge.

Tanzania & Madagascar.

Unclassified

Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

What reinfections mean for COVID-19

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target