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immunocompromised

From the National Cancer Institute: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/immunocompromised

Having a weakened immune system. People who are immunocompromised have a reduced ability to fight infections and other diseases. This may be caused by certain diseases or conditions, such as AIDS, cancer, diabetes, malnutrition, and certain genetic disorders. It may also be caused by certain medicines or treatments, such as anticancer drugs, radiation therapy, and stem cell or organ transplant. Also called immunosuppressed.

From a medical standpoint, major or significant immune suppression is found in people who have had organ transplants, cancer currently undergoing chemotherapy, HIV with reduced t-cell counts, or who are being treated with chronic corticosteroids, or biologic agents that are known immune modulators. There are many such drugs in current use, for disorders such as rheumatoid arthritis, lupus and cancer for example. Also there are rare genetic disorders of primary immunodeficiency that would put individuals in this group, but these usually become obvious in childhood.

Old age, diabetes mellitus, malnutrition and probably other factors (i.e. perhaps vitamin D deficiency) are associated with decreased immunity, but to a lesser or unknown degree.

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