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Hydroxychloroquine for the Prevention or Treatment of COVID-19
Rationale
The are numerous rationale for using HCQ as prophylaxis to prevent SARS-CoV-2 infection and as treatment for COVID-19 patients.
Prior Research
Antiviral Properties
Evidence Supporting HCQ as Prophylaxis
Evidence Supporting HCQ Use in Treatment
Controversy
From early on in the SARS-CoV-2 pandemic, a large and often vicious propaganda campaign was waged against HCQ's use in the prevention or treatment of SARS-CoV-2 and COVID-19.
Media Blitz
Tainted Research
Surgisphere: https://www.the-scientist.com/features/the-surgisphere-scandal-what-went-wrong--67955
Simpsons paradox Suboptimal trial protocols
Links to be Sorted
A paper from July 28, 2020, by Jeffrey Aronson and Robin Ferner on behalf of the Oxford COVID-19 Evidence Service Team which concludes that;
“The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans.”