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--- covid-19:risk_stratification [2021/12/26 12:22]
mathew created/imported
+++ covid-19:risk_stratification [2022/04/27 15:01] (current)
mathew
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 ====== COVID-19 Risk Stratification ======
+===== Summary Risk Research =====
+  * [[https://collections.nlm.nih.gov/master/borndig/101774952/Risk%20Factors%20for%20COVID-19%20Mortality%20among%20Privately%20Insured%20Patients%20-%20A%20Claims%20Data%20Analysis%20-%20A%20FAIR%20Health%20White%20Paper.pdf|Nov 11, 2020]] Dr. [[:Marty Makary]]: Risk Factors for COVID-19 Mortality among Privately Insured Patients
+    * 0.59% [[:Case Fatality Rate]] overall.
+    * Sex: 60.07% Male
+    * Age: 70+ was 4.82% of cases, but 42.43% of deaths
+    * Cancer: 2.89 to 6.74 odds ratio for mortality.
+    * Intellectual disabilities: 2.75 to 3.61 odds ratios.
+    * Comorbidities: 83.29% had at least one comorbidity.
+    * 0.01% CFR among 0-18.
+===== Genetic Stratification =====
+Protein expression lends itself to prediction of hospitalization and death from COVID-19 with high rates of accuracy.((October 19, 2021 | Science Daily | [[https://www.sciencedaily.com/releases/2021/10/211019082716.htm|Predicting patient death or hospitalization from COVID-19]]))
 ===== COVID-19 in Children =====
-The topic of **[[COVID-19]] in Children** has become an artificial controversy during the [[SARS-CoV-2 pandemic]], most likely due to the need to drive fear to encourage parents to offer up their children as medical experiments as part of the [[COVID-19 vaccine]] campaign.
+The topic of [[:COVID-19]] in children has become an artificial controversy during the [[:COVID-19 pandemic]], most likely due to the need to drive fear to encourage parents to offer up their children as medical experiments as part of the COVID-19 vaccine campaign.
 ==== Research Regarding COVID-19 in Children ====
+  * January 4, 2022: [[https://jamanetwork.com/journals/jamapediatrics/fullarticle/2787479 | Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection]]((Lauren C. Shuffrey, PhD; Morgan R. Firestein, PhD; Margaret H. Kyle, BA; et al )(2022) //JAMA Pediatr. Published online January 4, 2022. doi:10.1001/jamapediatrics.2021.5563//))
+  * August 1, 2021: [[https://publications.aap.org/hospitalpediatrics/article-abstract/11/8/e151/179740/For-COVID-or-With-COVID-Classification-of-SARS-CoV?redirectedFrom=fulltext|"For COVID" or "With COVID": Classification of SARS-CoV-2 Hospitalizations in Children.]]((Kushner, L. E., Schroeder, A. R., Kim, J., & Mathew, R. (2021). //“For COVID” or “With COVID”: Classification of SARS-CoV-2 Hospitalizations in Children.// Hospital Pediatrics, 11(8), e151–e156. https://doi.org/10.1542/hpeds.2021-006001))
+  * July 15, 2021: [[https://doi.org/10.1038/d41586-021-01897-w|Deaths from COVID ‘incredibly rare’ among children.]]((Ledford, H. (2021). //Deaths from COVID ‘incredibly rare’ among children.// Nature, 595(7869), 639. https://doi.org/10.1038/d41586-021-01897-w))
+  * April 2021: [[https://journals.lww.com/pidj/Fulltext/2021/04000/Risk_Factors_for_Severe_COVID_19_in_Children.2.aspx|Risk Factors for Severe COVID-19 in Children]]((Graff, K., Smith, C., Silveira, L., Jung, S., Curran-Hays, S., Jarjour, J., Carpenter, L., Pickard, K., Mattiucci, M., Fresia, J., McFarland, E. J., Dominguez, S. R., & Abuogi, L. (2021). //Risk Factors for Severe COVID-19 in Children.// The Pediatric Infectious Disease Journal, 40(4), e137. https://doi.org/10.1097/INF.0000000000003043))
+  * February 1, 2021: [[https://www.ijidonline.com/article/S1201-9712(20)32475-9/fulltext|Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis.]]((Kushner, L. E., Schroeder, A. R., Kim, J., & Mathew, R. (2021). //“For COVID” or “With COVID”: Classification of SARS-CoV-2 Hospitalizations in Children.// Hospital Pediatrics, 11(8), e151–e156. https://doi.org/10.1542/hpeds.2021-006001))
+  * January 1, 2021: [[https://publications.aap.org/pediatrics/article-abstract/147/1/e2020029736/33483/COVID-19-in-Children-Looking-Forward-Not-Back?redirectedFrom=fulltext|COVID-19 in Children: Looking Forward, Not Back.]]((Lee, B., & Raszka, W. V. (2020). //COVID-19 in Children: Looking Forward, Not Back.// Pediatrics, 147(1), e2020029736. https://doi.org/10.1542/peds.2020-029736))
+  * August 7, 2020: [[https://adc.bmj.com/content/106/7/709.info|Role of children in household transmission of COVID-19]]((Kim, J., Choe, Y. J., Lee, J., Park, Y. J., Park, O., Han, M. S., Kim, J.-H., & Choi, E. H. (2020). //Role of children in household transmission of COVID-19.// Archives of Disease in Childhood. https://doi.org/10.1136/archdischild-2020-319910
+))
+  * December 31, 2021 Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19 — Six Hospitals, United States, July–August 2021 [[https://www.cdc.gov/mmwr/volumes/70/wr/mm705152a3.htm?s_cid=mmmm705152a3_w]]
+=== Pediatric Mortality Rates ===
+  * From March 2020 through February 2021 (one year), there were only 61 children in the UK who died where COVID-19 was listed as a contributing factor.((November 11, 2021 | Clare Smith et al | [[:Nature Medicine]] | [[https://www.nature.com/articles/s41591-021-01578-1|DOI
+https://doi.org/10.1038/s41591-021-01578-1]]))
+=== Pediatric Hospitalization Rates ===
+  * COVID-19 and Children: ALL the Answers You Need in ONE PLACE((March 3, 2022 | [[:Justin Hart]] | [[https://covidreason.substack.com/p/covid-19-and-children-all-the-answers?s=r|COVID-19 and Children: ALL the Answers You Need in ONE PLACE]]))
+  * The most important papers on SARS-COV2 in kids((March 3, 2022 | Josh Stevenson | [[https://relevantdata.substack.com/p/the-most-important-papers-on-sars?s=w|The most important papers on SARS-COV2 in kids]]))
+  * Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany((November 30, 2021 | AL Sorg et al | Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany | [[https://www.medrxiv.org/content/10.1101/2021.11.30.21267048v1.full-text|doi: https://doi.org/10.1101/2021.11.30.21267048]]))
 === National Reports ===
@@ Line 23: / Line 55: @@
 No children have died due to COVID-19.
 https://brownstone.org/articles/sweden-and-germany-no-deaths-in-children-due-to-covid/
 ==== In the Media ====