Genetics

Mutation

Synonymous and Nonsynonymous Substitution Rates

When one or more nucleotides of a codon undergoes a single nucleotide polymorphism (SNP), the codon may code for the same amino acid (called a synonymous or “silent” mutation) or code for a different amino acid or even become a stop codon (called a nonsynonymous mutation).

  • Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models1)

Genetics Tools

BLAST

The Basic Local Alignment Search Toolkit (BLAST) is a tool often used to compare genetic sequences.

1)
January 1, 2000 | Ziheng Yang and Rasmus Nielsen | Molecular Biology and Evolution | Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models | https://doi.org/10.1093/oxfordjournals.molbev.a026236
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