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 Scientific Advisory Group for Emergencies (Sage) is advising cabinet on coronavirus response
-The Guardian by Ian Sample Science editor - Fri 24 Apr 2020
+The Guardian by [[Ian Sample]] Science editor - Fri 24 Apr 2020
 On Friday the Guardian revealed the 23 attendees of the Scientific Advisory Group for Emergencies (Sage). They comprise 21 scientists and two Downing Street political advisers.((https://web.archive.org/web/20200424182142/https://www.theguardian.com/world/2020/apr/24/coronavirus-whos-who-on-secret-scientific-group-advising-uk-government-sage))
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 An accomplished data scientist, [[:Ben Warner]] previously worked at his brother’s [[:AI]] company, which has teamed up with with [[:Palantir]], the US data firm founded by the rightwing billionaire [[:Peter Thiel]], to consolidate UK government databases to help ministers respond to the pandemic. ((https://web.archive.org/web/20200424182142/https://www.theguardian.com/world/2020/apr/24/coronavirus-whos-who-on-secret-scientific-group-advising-uk-government-sage))
+==== WHO's SAGE Safety Opinion ====
+{{ ::who_astra_zeneca_jab_safe_effective_sage.png?600|}}
+The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know
+June 2022
+العرب
+The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca [[:COVID-19 vaccine]] (ChAdOx1-S [recombinant] vaccine).
+You may access the guidance document here. ((https://www.who.int/publications/i/item/WHO-2019-nCoV-vaccines-SAGE_recommendation-AZD1222-2021.1))
+=== Who can be vaccinated? ===
+The vaccine is safe and effective for all individuals aged 18 and above. In line with the WHO Prioritization Roadmap and and the WHO Values Framework older adults, health workers and immunocompromised persons should be prioritised.
+The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. But individuals may choose to delay vaccination for 3 months following the infection.
+=== Should pregnant and breastfeeding women be vaccinated? ===
+WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. To help pregnant women make this assessment, they should be provided with information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women.
+WHO does not recommend pregnancy testing prior to vaccination. WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination.
+The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. WHO does not recommend discontinuing breastfeeding because of vaccination.
+Who is the vaccine not recommended for?
+People with a history of severe allergic reaction to any component of the vaccine should not take it.
+The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies.
+=== Is it safe? ===
+The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international impact.
+=== Is a booster dose recommended for this vaccine? ===
+A booster dose may be considered 4 – 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap.
+The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time.
+The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined.
+=== Can this vaccine be ‘mixed and matched’ with other vaccines? ===
+SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series.
+For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules:
+      * The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a first dose with the AstraZeneca vaccine dependant on product availability.
+  *     The Astra-Zeneca vaccine can be used as a second dose following any WHO EUL COVID-19 inactivated vaccines (Sinopharm, Sinovac or Bharat) dependant on product availability.
+When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. However, maintaining a homologous schedule is still acceptable.
+The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine.
+Does it prevent infection and transmission?
+**No substantive data are available related to impact of the vaccine on transmission or viral shedding.**
+In the meantime, we must maintain and strengthen public health and social measures that work: masking, physical distancing, handwashing, respiratory and cough hygiene, avoiding crowds, and ensuring good ventilation.
+((https://www.who.int/news-room/feature-stories/detail/the-oxford-astrazeneca-covid-19-vaccine-what-you-need-to-know))