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ralph_baric [2022/05/17 04:42]
pamela [Curriculum Vitae] 		ralph_baric [2022/09/17 22:53] (current)
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-====== Ralph S. Baric, PhD ======+====== Ralph Baric ======
  
 {{ ::baric.jpeg?150|}} {{ ::baric.jpeg?150|}}
  
-Professor in the Department of Epidemiology and Professor in the Department of Microbiology and Immunology\\+**Ralph S. Baric**, PhD is a Professor in the Department of Epidemiology and Professor in the Department of Microbiology and Immunology\\
 The University of North Carolina at Chapel Hill - Gillings School of Global Public Health\\ The University of North Carolina at Chapel Hill - Gillings School of Global Public Health\\
  
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 ==== Coronavirus Research  Timeline ==== ==== Coronavirus Research  Timeline ====
 +
 +=== 1992 ===
 +  * June 11, 1992 - Baric was part of a team that published research noting how rabbit coronavirus could cause [[heart]] and [[cardiovascular]] issue including [[cardiomyopathy]], [[myocardial fibrosis]], and [[congestive heart failure]].((June 11, 1992 | Lorraine Alexander et al | An Experimental Model for Dilated Cardiomyopathy after Rabbit Coronavirus Infection | [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109931/pdf/166-5-978.pdf]]))
  
 === 2013 === === 2013 ===
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   * The first listed subcontractor is Professor [[Ralph Baric]], referencing his "two-decade track record of reverse-engineer CoV and other virus spike proteins."   * The first listed subcontractor is Professor [[Ralph Baric]], referencing his "two-decade track record of reverse-engineer CoV and other virus spike proteins."
  
 +==== Gillings School of Global Public Health 2018  ====
  
 +11:50 a.m. – 12:25 p.m.{{ ::baric_20_18_prevent_pandemic_conference.png?800|}}
 +“Imagining the Next Flu Pandemic – and Preventing it!”
 +Ralph Baric, PhD, Professor, Epidemiology, Gillings School of Global Public Health; Professor, Microbiology and Immunology, School of Medicine; UNC-Chapel Hill
 +
 +Ralph Baric, PhD, presides over one of the leading labs in the world and works on infectious diseases such as [[:SARS]], [[:MERS]], [[:Ebola]], [[:Zika]], [[:Dengue Fever]] and [[:influenza]], among others. In particular, Dr. Baric and his research team specialize in [[:coronaviruses]] and emerging infections. **He uses coronaviruses as models to study the genetics of RNA virus transcription, replication, persistence and cross-species transmission.** 
 +
 +Dr. Baric received the Innovation Award for Faculty Research at UNC in 2011, the Established Investigator Award from the [[:American Heart Association]] in 1994 and was selected as a Harvey Weaver Scholar by the [[:National Multiple Sclerosis Society]]. Dr. Baric uses molecular, genetic and biochemical approaches to decipher the complex interactions between the virion and cell surface molecules that function in the entry and cross-species transmission of positive-strand RNA viruses.
 +
 +Selected publications:
 +
 +      * MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS (2018). Proceedings of the National Academy of Sciences, 115(5), E1012-E1021.
 +  *     Neutralization mechanism of a highly potent antibody against Zika virus. S Zhang, V Kostyuchenko, T Ng, X Lim, J Ooi, S Lambert, T Tan, D Widman, J Shi, R Baric, S Lok (2016). Nature communications, 7.
 +  *     SARS-like WIV1-CoV poised for human emergence. V Menachery, B Yount, A Sims, K Debbink, S Agnihothram, L Gralinski, R Graham, T Scobey, J Plante, S Royal, J Swanstrom, T Sheahan, R Pickles, D Corti, S Randell, A Lanzavecchia, W Marasco, R Baric (2016). Proceedings of the National Academy of Sciences of the United States of America.
 +  *     A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. V Menachery, B Yount, K Debbink, S Agnihothram, L Gralinski, J Plante, R Graham, T Scobey, X Ge, E Donaldson, S Randell, A Lanzavecchia, W Marasco, Z Shi, R Baric (2015). Nature medicine, 21(12), 1508-13.
 +  *     Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. Lisa Lindesmith, Martin Ferris, Clancy Mullan, Jennifer Ferreira, Kari Debbink, Jesica Swanstrom, Charles Richardson, Robert Goodwin, Frank Baehner, Paul Mendelman, Robert Bargatze, Ralph Baric (2015). PLoS Medicine, 12(3).
 +
 +12:25-12:40 p.m. - Moderated questions/discussion and wrap-up ((https://web.archive.org/web/20220908165230/https://sph.unc.edu/cphm/imagining-the-next-flu-pandemic-and-preventing-it/))
  
 ==== CoV Vaccine Research ==== ==== CoV Vaccine Research ====
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-===== Controversy During the COVID-19 Pandemic =====+===== Pandemics ===== 
 +Baric's career depends on funding associated with concern over [[pandemic|pandemics]], and [[biowarfare]]. 
 + 
 +==== Talks On Pandemics ==== 
 +  * Imagining the Next Flu Pandemic--and Preventing It!((April, 2018 | Ralph Baric | [[https://sph.unc.edu/nciph/1918-flu-symposium/|UNC Going Viral Conference]] | "Imagining the Next Flu Pandemic--and Preventing It!" | [[https://www.youtube.com/watch?v=UuERPvBFfco|Video at YouTube]])) 
 + 
 +==== Controversy During the COVID-19 Pandemic ====
  
-==== USRTK FOIA Archive ====+=== USRTK FOIA Archive ===
  
 Ralph Baric emails batch #1 (12.14.20) (83,416 pages). Dr. Ralph Baric’s emails with EcoHealth Alliance, Wuhan Institute of Virology, the U.S. National Academy of Sciences and experts in biodefense and infectious diseases.((https://www.dropbox.com/sh/6fbnvgw2i2a2ksv/AADfQOIVnUTvN3pJLmjr8irEa?dl=0)) Ralph Baric emails batch #1 (12.14.20) (83,416 pages). Dr. Ralph Baric’s emails with EcoHealth Alliance, Wuhan Institute of Virology, the U.S. National Academy of Sciences and experts in biodefense and infectious diseases.((https://www.dropbox.com/sh/6fbnvgw2i2a2ksv/AADfQOIVnUTvN3pJLmjr8irEa?dl=0))
  
-==== Congressional Investigation ==== +=== Congressional Investigation === 
 COVID Timeline with summary details at [[Peter Daszak]]. Full Report ((https://web.archive.org/web/20210802165023/https://gop-foreignaffairs.house.gov/wp-content/uploads/2021/08/ORIGINS-OF-COVID-19-REPORT.pdf))  COVID Timeline with summary details at [[Peter Daszak]]. Full Report ((https://web.archive.org/web/20210802165023/https://gop-foreignaffairs.house.gov/wp-content/uploads/2021/08/ORIGINS-OF-COVID-19-REPORT.pdf)) 
  
  
-==== Foreign Affairs Subcommittee Summary ====+=== Foreign Affairs Subcommittee Summary ===
 “As we continued our investigation into the origins of the [[COVID-19 pandemic]], we uncovered even more disturbing evidence about the [[Chinese Communist Party]]’s (CCP) coverup and [[WHO Director General Tedros]]’s gross mishandling of the virus that allowed it to turn into a deadly pandemic,” said Lead Republican [[Michael McCaul]]. “It is crystal clear that had the CCP been transparent, and had the head of the WHO cared more about global health than appeasing the CCP, lives could have been spared and widespread economic devastation could have been mitigated. Revealing the truth is just the first step; we must hold both the CCP and WHO Director General Tedros accountable for the suffering they have allowed the world to endure.”((https://web.archive.org/web/20210803114834/https://gop-foreignaffairs.house.gov/blog/mccaul-releases-final-report-on-origins-of-covid-19-pandemic/ | McCaul Final Report)) “As we continued our investigation into the origins of the [[COVID-19 pandemic]], we uncovered even more disturbing evidence about the [[Chinese Communist Party]]’s (CCP) coverup and [[WHO Director General Tedros]]’s gross mishandling of the virus that allowed it to turn into a deadly pandemic,” said Lead Republican [[Michael McCaul]]. “It is crystal clear that had the CCP been transparent, and had the head of the WHO cared more about global health than appeasing the CCP, lives could have been spared and widespread economic devastation could have been mitigated. Revealing the truth is just the first step; we must hold both the CCP and WHO Director General Tedros accountable for the suffering they have allowed the world to endure.”((https://web.archive.org/web/20210803114834/https://gop-foreignaffairs.house.gov/blog/mccaul-releases-final-report-on-origins-of-covid-19-pandemic/ | McCaul Final Report))
  
-=== Washington Post OpEd ===+== Washington Post OpEd ==
 New congressional report says covid-19 likely emerged in Wuhan months earlier than originally thought New congressional report says covid-19 likely emerged in Wuhan months earlier than originally thought
 by Josh Rogin Columnist by Josh Rogin Columnist
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 The Lancet commission on covid-19 removed Daszak from its team focusing on the origins of the pandemic after Daszak filed an updated conflict of interest statement about his collaboration with the Wuhan labs. McCaul wants him to be subpoenaed to testify and is demanding the EcoHealth Alliance hand over its relevant records to Congress.((https://web.archive.org/web/20210802234108/http://www.washingtonpost.com/opinions/2021/08/02/new-report-says-covid-emerged-in-wuhan-months-earlier/)) The Lancet commission on covid-19 removed Daszak from its team focusing on the origins of the pandemic after Daszak filed an updated conflict of interest statement about his collaboration with the Wuhan labs. McCaul wants him to be subpoenaed to testify and is demanding the EcoHealth Alliance hand over its relevant records to Congress.((https://web.archive.org/web/20210802234108/http://www.washingtonpost.com/opinions/2021/08/02/new-report-says-covid-emerged-in-wuhan-months-earlier/))
  
-==== Lab Leak Coverup ====+=== Lab Leak Coverup ===
  
 In April 2021, in an editorial in the journal Infectious Diseases & Immunity, Shi resorted to a familiar tactic to contain the cloud of suspicion enveloping her: She invoked scientific consensus, just as the Lancet statement had. “The scientific community strongly dismisses these unproven and misleading speculations and generally accepts that SARS-CoV-2 has a natural origin and was selected either in an animal host before zoonotic transfer, or in humans following zoonotic transfer,” she wrote. In April 2021, in an editorial in the journal Infectious Diseases & Immunity, Shi resorted to a familiar tactic to contain the cloud of suspicion enveloping her: She invoked scientific consensus, just as the Lancet statement had. “The scientific community strongly dismisses these unproven and misleading speculations and generally accepts that SARS-CoV-2 has a natural origin and was selected either in an animal host before zoonotic transfer, or in humans following zoonotic transfer,” she wrote.
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 Among the signers was Ralph Baric. Fifteen months earlier, he had worked behind the scenes to help Peter Daszak stage-manage the Lancet statement. The scientific consensus had been smashed to smithereens.((https://web.archive.org/web/20210603100523/https://www.vanityfair.com/news/2021/06/the-lab-leak-theory-inside-the-fight-to-uncover-covid-19s-origins)) Among the signers was Ralph Baric. Fifteen months earlier, he had worked behind the scenes to help Peter Daszak stage-manage the Lancet statement. The scientific consensus had been smashed to smithereens.((https://web.archive.org/web/20210603100523/https://www.vanityfair.com/news/2021/06/the-lab-leak-theory-inside-the-fight-to-uncover-covid-19s-origins))
  
-==== Biosafety at University of North Carolina (UNC) ====+=== Biosafety at University of North Carolina (UNC) ===
  
  
-=== Engineered COVID-19-Infected Mouse Bites Researcher Amid ‘Explosion’ of Risky Coronavirus Research ===+== Engineered COVID-19-Infected Mouse Bites Researcher Amid ‘Explosion’ of Risky Coronavirus Research ==
 by Jonathan Latham August 17, 2020  by Jonathan Latham August 17, 2020 
  
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 In part this is because the minutes of the relevant IBC meeting (May 6th, 2020, p109) are extremely brief. They do not provide any details of the fate of the bitten researcher. Nor do they state, for example, whether the researcher developed an active infection, nor whether they developed symptoms, nor if they transmitted the recombinant virus to anyone else. Neither do they reveal what kind of [[recombinant virus]] was being used or the purpose of the experiment. ((https://web.archive.org/web/20220120184413/https://www.independentsciencenews.org/news/engineered-covid-19-infected-mouse-bites-researcher-amid-explosion-of-risky-coronavirus-research/)) In part this is because the minutes of the relevant IBC meeting (May 6th, 2020, p109) are extremely brief. They do not provide any details of the fate of the bitten researcher. Nor do they state, for example, whether the researcher developed an active infection, nor whether they developed symptoms, nor if they transmitted the recombinant virus to anyone else. Neither do they reveal what kind of [[recombinant virus]] was being used or the purpose of the experiment. ((https://web.archive.org/web/20220120184413/https://www.independentsciencenews.org/news/engineered-covid-19-infected-mouse-bites-researcher-amid-explosion-of-risky-coronavirus-research/))
  
-=== Redactions of Biosafety Committee discussions ===+== Redactions of Biosafety Committee discussions ==
  
 The second reason for this lack of information is that the UNC redacted the names of [[Principal Investigators]] (PIs) whose research required biosafety scrutiny, along with many of the experimental specifics. The second reason for this lack of information is that the UNC redacted the names of [[Principal Investigators]] (PIs) whose research required biosafety scrutiny, along with many of the experimental specifics.
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-==== Wuhan BSL Connection ====+=== Wuhan BSL Connection ===
 Inside the risky bat-virus engineering that links America to Wuhan Inside the risky bat-virus engineering that links America to Wuhan
 China emulated US techniques to construct novel coronaviruses in unsafe conditions. China emulated US techniques to construct novel coronaviruses in unsafe conditions.
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 Unnoticed by most, however, was a key difference that significantly shifted the risk calculation. The Chinese work was carried out at biosafety level 2 (BSL-2), a much lower tier than Baric’s BSL-3+.((https://web.archive.org/web/20220207131353/https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan)) Unnoticed by most, however, was a key difference that significantly shifted the risk calculation. The Chinese work was carried out at biosafety level 2 (BSL-2), a much lower tier than Baric’s BSL-3+.((https://web.archive.org/web/20220207131353/https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan))
-==== Did Ralph Baric of UNC Design Omicron? ====+ 
 +=== Did Ralph Baric of UNC Design Omicron? ===
 "COVID Bioweapon Against Mice" Patent 11225508 "COVID Bioweapon Against Mice" Patent 11225508
 March 30, 2022 by Igor Chudov  March 30, 2022 by Igor Chudov 
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 Publication date: July 23, 2020 Publication date: July 23, 2020
 Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom ((https://web.archive.org/web/20210214225023/https://patents.justia.com/inventor/ralph-baric)) Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom ((https://web.archive.org/web/20210214225023/https://patents.justia.com/inventor/ralph-baric))
 +
 +{{tag>Pro-narrative_scientists}}
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