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covid-19:treatments:drug_therapies:hydroxychloroquine [2022/01/02 10:02]
mathew 		covid-19:treatments:drug_therapies:hydroxychloroquine [2022/10/05 01:02] (current)
mathew
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 ==== Prior Research ==== ==== Prior Research ====
 Since shortly after the first [[:SARS-CoV]] outbreak, researchers compiled evidence that chloroquine and hydroxychloroquine would likely help fight another deadly [[:coronavirus]] outbreak.((Mar 25, 2021 | [[:Rounding The Earth]] | [[https://roundingtheearth.substack.com/p/the-chloroquine-wars-part-vii|Why Did Dr. Anthony Fauci Leave Hydroxychloroquine Off the Early Pandemic Research Priority List?]])) Since shortly after the first [[:SARS-CoV]] outbreak, researchers compiled evidence that chloroquine and hydroxychloroquine would likely help fight another deadly [[:coronavirus]] outbreak.((Mar 25, 2021 | [[:Rounding The Earth]] | [[https://roundingtheearth.substack.com/p/the-chloroquine-wars-part-vii|Why Did Dr. Anthony Fauci Leave Hydroxychloroquine Off the Early Pandemic Research Priority List?]]))
 +  * In 2005, researcher Martin Vincent and colleagues noted that chloroquine is a potent inhibitor of SARS coronavirus infection and spread.((August 22, 2005 | Vincent et al | [[:Virology Journal]] | [[https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69|doi: 10.1186/1743-422X-2-69]]))
  
-==== Antiviral Properties Research ==== +==== Antiviral Properties Research (Mechanisms) ==== 
 +  * Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture((September 14, 2022 | Zixuan Yuan et al | Nature (journal) | Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture | [[https://www.nature.com/articles/s42003-022-03841-8|doi.org/10.1038/s42003-022-03841-8]]))
  
 ===== Evidence for Prophylaxis ===== ===== Evidence for Prophylaxis =====
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 "The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans." "The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans."
  
 +  * [[https://www.cureus.com/articles/76496-therapies-to-prevent-progression-of-covid-19-including-hydroxychloroquine-azithromycin-zinc-and-vitamin-d3-with-or-without-intravenous-vitamin-c-an-international-multicenter-randomized-trial|Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial]]
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