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sars-cov-2:genetics_of_sars-cov-2

Genetics of SARS-CoV-2

The genetics of SARS-CoV-2 has been controversial due to the debates over gain-of-function research and the origins story of the virus that led to COVID-19 pandemic policies.

Genetic RNA Structure

Codons

Early analysis of the genetics of SARS-CoV-2 which included examination of relative synonymous codon usage (RSCU) showed greatest similarity of genetic information with bat CoVs, but had most similar codon bias usage with snakes.1)

  • Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic2)

Gain-of-Function

Specific Sequences

TATCAGACTCAGACTAATTCTCCTCGGCGGGCACGT

  • Gain-of-Function Smashing Success: The Key Sequence Inserted in the SARS-CoV-2 Virus Added at Least *FOUR* Distinct Functions. Coincidence?3)

SEB Insert

Researchers found that that a monoclonal antibody against SEB inhibits SARS-CoV-2 entry in vitro.4) It is interesting to note that the preprint of this paper was uploaded on November 24, 2020, but went unpublished for more than 9 months.

Data Controversies

1)
January 22, 2020 | Wei Ji et al | Journal of Medical Virology | Cross-species transmission of the newly identified coronavirus 2019-nCoV | https://doi.org/10.1002/jmv.25682
2)
December 17, 2021 | Ezequiel Mogro et al | preprint | Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic | https://doi.org/10.1101/2021.12.17.472912
4)
September 2, 2021 | Mary Hongying Cheng et al | Structure (journal) | A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro | doi: 10.1016/j.str.2021.04.005
sars-cov-2/genetics_of_sars-cov-2.txt · Last modified: 2022/05/09 06:49 by mathew