You are here: Welcome » SARS-CoV-2

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision
Previous revision
Both sides next revision
sars-cov-2 [2022/03/03 12:18]
liam
sars-cov-2 [2022/09/19 04:39] (current)
pamela
Line 1: Line 1:
 ====== SARS-CoV-2 ====== ====== SARS-CoV-2 ======
  
-{{ ::screen_shot_2022-03-03_at_3.16.04_am.png?200|}}+{{ ::screen_shot_2022-03-03_at_3.16.04_am.png?400|}}
  
 **SARS-CoV-2** is a humanborne [[coronavirus]] in the //[[betacoronavirus]]// family. The emergence of SARS-CoV-2 led to the [[SARS-CoV-2 pandemic]] to be declared by the [[World Health Organization]]. **SARS-CoV-2** is a humanborne [[coronavirus]] in the //[[betacoronavirus]]// family. The emergence of SARS-CoV-2 led to the [[SARS-CoV-2 pandemic]] to be declared by the [[World Health Organization]].
  
-SARS-CoV-2 is an acronym, which stands for Severe Acute Respiratory Syndrome Coronavirus 2. It is named as such due to its relative similarity to the [[SARS-CoV-1|SARS coronavirus]] that led to a public health emergency in parts of the world in 2003.+SARS-CoV-2 stands for Severe Acute Respiratory Syndrome Coronavirus 2. It is named as such due to its relative similarity to the [[SARS-CoV-1|SARS coronavirus]] that led to a public health emergency in parts of the world in 2003.((Wu, Y., Ho, W., Huang, Y., Jin, D.-Y., Li, S., Liu, S.-L., Liu, X., Qiu, J., Sang, Y., Wang, Q., Yuen, K.-Y., & Zheng, Z.-M. (2020). //SARS-CoV-2 is an appropriate name for the new coronavirus.// The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)30557-2)) ((Feng, D., De Vlas, S. J., Fang, L., Han, X., Zhao, W., Sheng, S., Yang, H., Jia, Z., Richardus, J. H., & Cao, W. (2009). //The SARS epidemic in mainland China: bringing together all epidemiological data.// Tropical Medicine & International Health, 14(Suppl 1), 4–13. https://doi.org/10.1111/j.1365-3156.2008.02145.x))
  
 +The SARS-CoV-2 virus is a close genetic relative of two other infamous viruses from recent history: [[SARS-CoV-1|SARS-CoV]] and [[MERS-CoV]].((Rabaan, A. A., Al-Ahmed, S. H., Haque, S., Sah, R., Tiwari, R., Malik, Y. S., Dhama, K., Yatoo, M. I., Bonilla-Aldana, D. K., & Rodriguez-Morales, A. J. (2020). //SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview.// Le infezioni in medicina, 28(2), 174–184.))
  
 +
 +{{ ::sars-cov-2_genome_match_2015_studies.png?400|}}
 Related Pages: Related Pages:
   * [[SARS-CoV-2:Origins]]   * [[SARS-CoV-2:Origins]]
 +  * [[SARS-CoV-2:Genetics of SARS-CoV-2]]
   * [[SARS-CoV-2:Spike Protein]]   * [[SARS-CoV-2:Spike Protein]]
   * [[SARS-CoV-2:Surveillance and Testing]]   * [[SARS-CoV-2:Surveillance and Testing]]
   * [[SARS-CoV-2:Variants]]   * [[SARS-CoV-2:Variants]]
     * [[SARS-CoV-2:Omicron]]     * [[SARS-CoV-2:Omicron]]
- +  * [[COVID-19]] 
 +    * [[COVID-19 Pandemic]] 
 +    * [[COVID-19 Vaccines]] 
 +threadreader for inage ((https://web.archive.org/web/20220917230646/https://threadreaderapp.com/thread/1571168157754089479.html))
 ===== SARS-CoV-2 Viral Mechanisms and Characteristics ===== ===== SARS-CoV-2 Viral Mechanisms and Characteristics =====
 SARS-CoV-2 is a positively charged, single-stranded [[RNA virus]]. SARS-CoV-2 is a positively charged, single-stranded [[RNA virus]].
  
 ==== Features ==== ==== Features ====
 +  * [[SARS-CoV-2:Genetics of SARS-CoV-2]]
   * [[SARS-CoV-2:Spike protein]]   * [[SARS-CoV-2:Spike protein]]
   * [[SARS-CoV-2:Furin Cleavage Site]]   * [[SARS-CoV-2:Furin Cleavage Site]]
Line 25: Line 32:
 ==== Pathology ==== ==== Pathology ====
   * Dec, 2020 - Liao et al; SARS-CoV-2 in the bile of a patient with COVID-19-associated gallbladder disease.((December, 2020 | Liao et al | Endoscopy (journal) | SARS-CoV-2 in the bile of a patient with COVID-19-associated gallbladder disease | [[https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1290-7446|doi: 10.1055/a-1290-7446]]))   * Dec, 2020 - Liao et al; SARS-CoV-2 in the bile of a patient with COVID-19-associated gallbladder disease.((December, 2020 | Liao et al | Endoscopy (journal) | SARS-CoV-2 in the bile of a patient with COVID-19-associated gallbladder disease | [[https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1290-7446|doi: 10.1055/a-1290-7446]]))
 +
 +Researchers have found in autopsies that SARS-CoV-2 does get into brain tissue, and can be present for months after infection, though inflammation outside of the lungs was mild.((December 20, 2021 | Daniel Chertow et al | Nature Portfolio (journal) | SARS-CoV-2 infection and persistence throughout the human body and brain | [[https://www.researchsquare.com/article/rs-1139035/v1|doi.org/10.21203/rs.3.rs-1139035/v1]]))
 +
 +See [[SARS-CoV-2:Spike Protein]] for a discussion of [[:toxins]].
  
 ==== Transmission and Infectivity ==== ==== Transmission and Infectivity ====
Line 60: Line 71:
  
 == Infectivity in Animal Hosts == == Infectivity in Animal Hosts ==
 +[[https://vis.csh.ac.at/sars-ani/#infections|COVID-19 animal infection tracker]]
 +
 Numerous animals aside from humans have been noted to be susceptible to SARS-CoV-2 infection. Comparative and structural analysis on 410 vertebrate species predicts a broad host range for infection, specifically among mammals.((September 8, 2020 | Damas et al | [[:Proceedings of the National Academy of Sciences|PNAS]] | [[https://www.pnas.org/content/117/36/22311|doi.org/10.1073/pnas.2010146117]])) Numerous animals aside from humans have been noted to be susceptible to SARS-CoV-2 infection. Comparative and structural analysis on 410 vertebrate species predicts a broad host range for infection, specifically among mammals.((September 8, 2020 | Damas et al | [[:Proceedings of the National Academy of Sciences|PNAS]] | [[https://www.pnas.org/content/117/36/22311|doi.org/10.1073/pnas.2010146117]]))
 One study still in preprint found SARS-CoV-2 moving rapidly into white-tailed deer populations in North America, with over 80% of the deer testing PCR positive for the virus by early 2021.((November 6, 2021 | Kuchipudi et al | preprint | [[https://www.biorxiv.org/content/10.1101/2021.10.31.466677v2|doi.org/10.1101/2021.10.31.466677]])) One study still in preprint found SARS-CoV-2 moving rapidly into white-tailed deer populations in North America, with over 80% of the deer testing PCR positive for the virus by early 2021.((November 6, 2021 | Kuchipudi et al | preprint | [[https://www.biorxiv.org/content/10.1101/2021.10.31.466677v2|doi.org/10.1101/2021.10.31.466677]]))
- 
- 
-===== Disease ===== 
- 
-==== COVID-19 ==== 
-SARS-CoV-2 is a cause of [[COVID-19]], a disease with wide ranging characteristics primarily affecting the respiratory and vascular sysems. 
  
 ==== Immunity ==== ==== Immunity ====
Line 77: Line 84:
 === Natural Immunity === === Natural Immunity ===
 See [[COVID-19:natural immunity]]. See [[COVID-19:natural immunity]].
 +
 +=== Reinfections ===
 +During the early part of the COVID-19 pandemic, physicians and scientists found that reinfections were extremely rare.((May 19, 2020 | ScienceNews.org | [[https://www.sciencenews.org/article/coronavirus-covid19-reinfection-immune-response|New data suggest people aren’t getting reinfected with the coronavirus]]))
 +
 +During the omicron era, reinfections are rapidly on the rise.((March 21, 2022 | [[:Igor Chudov]] | [[https://igorchudov.substack.com/p/uk-short-term-reinfections-exploding?s=r|UK: Short-term Reinfections Exploding]]))
 +
 +=== Transference of Immunity ===
 +Scientists have noted evidence for aerosol transfer of SARS-CoV-2-specific humoral immunity.((May 1, 2022 | Kedl et al | preprint | Evidence for Aerosol Transfer of SARS-CoV2-specific Humoral Immunity | [[https://www.medrxiv.org/content/10.1101/2022.04.28.22274443v1.full#F1|doi.org/10.1101/2022.04.28.22274443]]))
 +
 +
 +
 +===== Disease =====
 +
 +==== COVID-19 ====
 +SARS-CoV-2 is a cause of [[COVID-19]], a disease with wide ranging characteristics primarily affecting the [[respiratory]] and [[vascular]] systems.
 +
 +==== Genetic and Epigenetic Effects of Infection ====
 +
 +=== Chromatin Architecture ===
 +  * SARS-CoV-2 Restructures the Host Chromatin Architecture((July 21, 2021 | Ruoyu Wang et al | preprint | [[https://www.biorxiv.org/content/10.1101/2021.07.20.453146v1.full|doi: https://doi.org/10.1101/2021.07.20.453146]]))
 +
 +
  
 ===== Mutation and Variants ===== ===== Mutation and Variants =====
Line 83: Line 112:
 See more at [[SARS-CoV-2:Variants|SARS-CoV-2 Variants]] See more at [[SARS-CoV-2:Variants|SARS-CoV-2 Variants]]
  
 +===== Controversies =====
  
-===== SARS-CoV-2 Origins Story Controversy =====+==== SARS-CoV-2 Origins Story Controversy ====
 The [[SARS-CoV-2:origins|origins of SARS-CoV-2]] are shrowded in mystery, including whether the virus is zoonotic or manmade, or was released accidentially or intentionaly. The [[SARS-CoV-2:origins|origins of SARS-CoV-2]] are shrowded in mystery, including whether the virus is zoonotic or manmade, or was released accidentially or intentionaly.
 +
 +==== Retracted Research ====
 +Many papers have been retracted during the [[COVID-19 pandemic]]. Here are some that relate specifically to SARS-CoV-2, though others may be found at [[Retraction Watch]].
 +  * SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro((October 13, 2021 | Jiang and Mei | Viruses (journal) | SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro | [[https://pubmed.ncbi.nlm.nih.gov/34696485/|doi: 10.3390/v13102056]]))
Back to top