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--- ivermectin [2022/08/21 20:33]
pamela
+++ ivermectin [2022/10/13 19:03] (current)
pamela [Mainstream Media Campaign]
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 ===== Ivermectin =====
-**Ivermectin** is an [[:antiparasitic]] agent with antiviral properties that is approved by the FDA and WHO for a myriad of treatments. It is listed as an essential medicine by the WHO.
+**Ivermectin** is an [[antiparasitic]] agent with [[antiviral]] properties that is approved by the FDA and the [[World Health Organization]] for a myriad of treatments. It is listed as an essential medicine by the WHO.
 The bacterium Streptomyces avermictilis was first discovered in the soils of Japan in the 1960s by Satoshi Ōmura while searching for new antibacterial agents. After some altering to improve its safety the resulting compound was dubbed ivermectin. It was first approved for use in animals in 1981 and later in 1987 for the treatment of river blindness in sub-Saharan Africa. Since then Merck Laboratories have donated billions of doses globally for the treatment of onchocerciasis and lymphatic filariasis and other worm-caused diseases. William C.
 A paper titled 'Ivermectin, ‘Wonder drug’ from Japan: the human use perspective' by Crump & Omura.(([[https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3043740/ | 'Ivermectin, ‘Wonder drug’ from Japan: the human use perspective']]))
+===== Ivermectin's Discovery and Recognition =====
+==== 2015 Nobel Prize ====
 In 2015 [[William Campbell]] and [[Satoshi Ömura]] were awarded a [[Nobel Prize]] for the drug.((https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539925/))((https://www.isglobal.org/en/healthisglobal/-/custom-blog-portlet/ivermectina-del-suelo-a-las-lombrices-y-mas-alla/3098670/0))
-**The Global Disinformation Campaign Against Ivermectin in COVID-19 (Part I)** is a Substack piece, written by [[:Pierre Kory]] on January 6, 2021.((https://pierrekory.substack.com/p/the-global-disinformation-campaign?))
+===== Antiparasitic Usage =====
+==== Malaria Treatment ====
+Research indicates that mass administration of ivermectin lowers [[malaria]] rates with essentially no side effects.((March 13, 2019 | Brian D Foy et al | [[The Lancet]] | Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial | [[https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32321-3/fulltext|https://doi.org/10.1016/S0140-6736(18)32321-3]]))
+{{ ::chris_whitty_2010_ivermectin_study.png?600|}}
+Effect of Ivermectin on Anopheles gambiae Mosquitoes Fed on Humans: The Potential of Oral Insecticides in Malaria Control
+Carlos Chaccour, Jo Lines, [[:Christopher J. M. Whitty]]
+The Journal of Infectious Diseases, Volume 202, Issue 1, 1 July 2010, Pages 113–116, https://doi.org/10.1086/653208
+Published: 01 July 2010
+==== Veterinary Usage ====
+Quote [[:Chris Whitty]]: "Ivermectin has a wide antiparasitic activity with long veterinary use [4]. When ivermectin's activity against [[Onchocerca volvulus]] was discovered, it was licensed for human use and was used in mass drug administration programs to control river blindness; it was administered to >80 million adults and children. The drug has proven to be safe. Doses up to 10 times the approved limit are well tolerated by healthy volunteers [5]. Adverse reactions are few and usually mild [6, 7]." ((https://web.archive.org/web/20220127114341/https://academic.oup.com/jid/article/202/1/113/888773?login=false))
+===== Controversy During the COVID-19 Pandemic =====
+During the [[COVID-19 pandemic]], the use of ivermectin to prevent or treat [[COVID-19]] became highly controversial.
+==== The Global Disinformation Campaign Against Ivermectin in COVID-19 (Part I) ====
+Pierre Kory’s Medical Musings Substack by [[:Pierre Kory]] on January 6, 2021.
+Ivermectin, a decades-old, off-patent drug costing pennies to make, with an unparalleled safety profile and numerous manufacturers across the world, actually sits atop one of the largest and strongest clinical trials evidence base in history. The existing, massive amount of clinical trials data shows immense efficacy against COVID-19 in all its phases; prevention, early and late treatment, and long-haul syndrome (no actual trials in long-haul but rather extensive positive clinical experiences). Despite this inarguable (yes, inarguable) supportive evidence, no major Western or international health agency has recommended its use in COVID-19. Conversely, ivermectin has been officially adopted for early treatment in all or part of 23 “less developed” countries (39 if you include non-government medical organizations), and which include about 25% of the world’s population.
+Now, before we delve deeper into the workings of the most heinous disinformation campaign ever waged by the pharmaceutical industry in history (and also it’s most successful so far as 75% of the earth’s inhabitants still have not been recommended to use it to treat COVID), I will ask you not to just “take my word for it" but instead take you on a brief, guided tour of the insanely positive evidence base supporting the use of ivermectin in COVID-19. ((https://pierrekory.substack.com/p/the-global-disinformation-campaign))
 See also ((covid-19:treatments:drug_therapies:ivermectin|Ivermectin as a treatment for COVID-19))
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 ==== Mainstream Media Campaign ====
-Touted in the mainstream press as "horse dewormer," ivermectin is that and more. It is important to take into consideration that any acceptance of ivermectin as a viable treatment for covid-19 puts at risk the vaccination campaign under Emergency Use Authorization and all policies associated with it.
+Touted in the mainstream press as "horse dewormer," ivermectin is that and more. It is important to take into consideration that any acceptance of ivermectin as a viable treatment for covid-19 puts at risk the vaccination campaign under [[:Emergency Use Authorization]] and all policies associated with it.
 August 26 2021, the CDC issued a ((https://emergency.cdc.gov/han/2021/pdf/CDC_HAN_449.pdf | Health Advisory)) titled "Rapid Increase in Ivermectin Prescriptions and Reports of Severe Illness Associated with Use of Products Containing Ivermectin to Prevent or Treat COVID-19". It later emerged that this was based on scant evidence; just three cases of alleged ivermectin side effects, two involving animal formulations. No patient died; one appeared to have been hospitalized, and one declined any medical help.
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 ==== SARS-CoV-2 Pandemic ====
-==Research Gate, February 2022 == DOI:10.13140/RG.2.2.20069.68320
+=== Research Gate, February 2022 ===
+DOI:10.13140/RG.2.2.20069.68320
 Strictly regular use of ivermectin as [[:prophylaxis]] for COVID-19 leads to a 90% reduction in [[COVID-19]] mortality rate, in a dose-response manner: definitive results of a prospective observational study of a strictly controlled 223,128 population from a city-wide program in Southern Brazil.