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hydroxychloroquine [2022/06/07 06:52] mathew | hydroxychloroquine [2022/09/19 01:50] pamela [Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture] | ||
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There was one single rationale paper for repurposing medicine published during the early going of the pandemic that did not include any discussion at all of hydroxychloroquine, | There was one single rationale paper for repurposing medicine published during the early going of the pandemic that did not include any discussion at all of hydroxychloroquine, | ||
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+ | ==== Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture ==== | ||
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+ | Published: 14 September 2022 {{ :: | ||
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+ | Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture | ||
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+ | Zixuan Yuan, Mahmud Arif Pavel, Hao Wang, Jerome C. Kwachukwu, Sonia Mediouni, Joseph Anthony Jablonski, Kendall W. Nettles, Chakravarthy B. Reddy, Susana T. Valente & Scott B. Hansen | ||
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+ | Communications Biology volume 5, Article number: 958 (2022) Cite this article | ||
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+ | Abstract | ||
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+ | [[: | ||
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+ | Recently, anesthetics were shown to disrupt ordered clusters of monosialotetrahexosylganglioside1 (GM1) lipid. These same lipid clusters recruit the [[: | ||
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+ | Here we employed super-resolution imaging of cultured mammalian cells (VeroE6, A549, H1793, and HEK293T) to show HCQ directly perturbs clustering of ACE2 receptor with both endocytic lipids and PIP2 clusters. In elevated (high) cholesterol, | ||
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+ | We conclude** HCQ inhibits viral entry through two distinct mechanisms** in high and low tissue cholesterol and does so prior to inhibiting cathepsin-L. HCQ clinical trials and animal studies will need to account for tissue cholesterol levels when evaluating dosing and efficacy. ((https:// | ||
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