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genetics [2022/02/06 11:02]
mathew created
genetics [2022/06/06 12:31] (current)
mathew
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 ====== Genetics ====== ====== Genetics ======
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 +===== Mutation =====
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 +==== Synonymous and Nonsynonymous Substitution Rates ====
 +When one or more nucleotides of a [[codon]] undergoes a [[single nucleotide polymorphism]] (SNP), the codon may code for the same [[amino acid]] (called a synonymous or "silent" mutation) or code for a different amino acid or even become a stop codon (called a nonsynonymous mutation).
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 +  * Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models((January 1, 2000 | Ziheng Yang and Rasmus Nielsen | [[Molecular Biology and Evolution]] | Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models | [[https://academic.oup.com/mbe/article/17/1/32/975527|https://doi.org/10.1093/oxfordjournals.molbev.a026236]]))
  
  
 ===== Genetics Tools ===== ===== Genetics Tools =====
 +  * [[https://nebiocalculator.neb.com/|NEBioCalculator]] with mass/moles/nucleic sequence converters.
  
 ==== BLAST ==== ==== BLAST ====
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   * U.S. National Library of Medicine [[https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome|online BLAST tool]].   * U.S. National Library of Medicine [[https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome|online BLAST tool]].
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