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fluvoxamine [2022/01/14 20:00]
brian 		fluvoxamine [2022/05/27 18:11] (current)
pamela
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 ==Story of Discovery== ==Story of Discovery==
-[[Angela Reiersen]] was the first to propose Fluvoxamine as a treatment for Covid-19 in March 2020.+[[Angela Reiersen]] was the first to propose Fluvoxamine as a treatment for Covid-19 in March 2020. Reierson remembered learning about the ability of FLV to protect mice from lethal septic shock and dampen the inflammatory response in human blood leukocytes from a 2019 journal article in //Science Translational Medicine//.((https://www.science.org/doi/10.1126/scitranslmed.aau5266)) 
  
 The first published paper that proposed FLV's S1R agonist mechanism of action against Covid-19 was //"What Were You Before the War?" Repurposing Psychiatry During the COVID-19 Pandemic//.((https://www.psychiatrist.com/jcp/covid-19/repurposing-psychiatry-during-covid/)) The first published paper that proposed FLV's S1R agonist mechanism of action against Covid-19 was //"What Were You Before the War?" Repurposing Psychiatry During the COVID-19 Pandemic//.((https://www.psychiatrist.com/jcp/covid-19/repurposing-psychiatry-during-covid/))
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 A pre-print Meta-Analysis posted on December 21, 2021 concluded that FLV has a high probability of preventing hospitalization from Covid-19(([[https://www.medrxiv.org/content/10.1101/2021.12.17.21268008v1|Fluvoxamine for Outpatient COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-Analysis]])) A pre-print Meta-Analysis posted on December 21, 2021 concluded that FLV has a high probability of preventing hospitalization from Covid-19(([[https://www.medrxiv.org/content/10.1101/2021.12.17.21268008v1|Fluvoxamine for Outpatient COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-Analysis]]))
  
 +==Presentations==
 +[[https://www.youtube.com/watch?v=7xWbY7HVZUM|The TOGETHER Study Shows that Fluvoxamine Reduces Risk of Prolonged Hospitalization]] by Certara
 +
 +Dr. [[Eric Lenze]] gave a presentation on FLV for Covid on 20 Aug 2021(([[https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-08-20-21.pdf|New treatments for mental disorders Why we’ve failed…and how we will succeed.]]))
  
-== Related ==+=== Related News ===
 [[https://www.instagram.com/p/CXo0DhBD8z9/|Dr. Pater Attia's instagram post on fluvoxamine]] [[https://www.instagram.com/p/CXo0DhBD8z9/|Dr. Pater Attia's instagram post on fluvoxamine]]
 Dr. Peter Attia describes how one of the physicians in his practice tried to prescribe fluvoxamine for a patient who had just gotten COVID. They called in the prescription to a CVS in California, and the pharmacist told them they would not fill it because it was not part of the “official COVID guideline.” Dr. Peter Attia describes how one of the physicians in his practice tried to prescribe fluvoxamine for a patient who had just gotten COVID. They called in the prescription to a CVS in California, and the pharmacist told them they would not fill it because it was not part of the “official COVID guideline.”
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 Finding a possible early treatment for COVID-19 in a 40-year-old antidepressant]]** Finding a possible early treatment for COVID-19 in a 40-year-old antidepressant]]**
  
-===Presentations=== 
-[[https://www.youtube.com/watch?v=7xWbY7HVZUM|The TOGETHER Study Shows that Fluvoxamine Reduces Risk of Prolonged Hospitalization]] by Certara 
  
-Dr. [[Eric Lenze]] gave a presentation on FLV for Covid on 20 Aug 2021(([[https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-08-20-21.pdf|New treatments for mental disorders Why we’ve failed…and how we will succeed.]]))+==== The TOGETHER Study on Fluvoxamine Was Not Free of Errors, Either ==== 
 +A First Look at the Numbers by Alexandros Marinos  
 + 
 +This article is part of a series on the [[:TOGETHER trial]]. More articles from this series here.((https://doyourownresearch.substack.com/p/together-trial-index-of-articles?s=w)) 
 + 
 +Today, I'll show you one more example of how the TOGETHER trial outputs seem quite willing to blur various boundaries, and always in ways in which help them promote their desired outcome. This particular example is from the fluvoxamine arm of the study. 
 + 
 +In a way, you can see this as a demonstration of how tugging at a fairly small thing that looks strange can unearth a whole world of concerning issues about a trial. So let’s see ((https://doyourownresearch.substack.com/p/the-together-study-on-fluvoxamine?s=w)) 
  
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