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covid-19:natural_immunity [2022/01/04 02:12]
mathew
covid-19:natural_immunity [2022/08/18 08:15] (current)
mathew
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 ====== SARS-CoV-2/COVID-19 Natural Immunity ====== ====== SARS-CoV-2/COVID-19 Natural Immunity ======
-**[[:COVID-19]] [[:natural immunity]]** is a controversial topic during the [[:COVID-19 pandemic]].+**[[:COVID-19]] [[:natural immunity]]** is a controversial topic during the [[:COVID-19 pandemic]], perhaps because it conflicts with what appears to be a highly determined plan to mass vaccinate the world.
  
 ===== Research ===== ===== Research =====
 +
 +==== T Cell Immunity ====
 +Both symptomatic and asymptomatic SARS-CoV-2 infections result in T cell responses, with greater interferon-\alpha producing responses from those with symptomatic infections.((March 5, 2021 | Prasanna Jagannathan & Taia Wang | Nature Immunology | Immunity after SARS-CoV-2 infections | [[https://www.nature.com/articles/s41590-021-00923-3|https://doi.org/10.1038/s41590-021-00923-3]]))
 +
 +==== Observational Studies ====
 +A group of scientists examined a wide swath of antibody data among Canadians during the first half of 2020 determining that more than 90% of uninfected adults showed preexisting antibody reactivity against SARS-CoV-2.((March 15, 2021 | Majdoubi et al | JCI Insight | A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2 | [[https://insight.jci.org/articles/view/146316|DOI:10.1172/jci.insight.146316]]))
 +
 +"SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021." Gazit et al., August 2021.((https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1))
 +
  
 ==== Empirical Studies ==== ==== Empirical Studies ====
  
-Iliaki et al found zero reinfections in a study of urban [[:health care worker]]s. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523483/+Iliaki et al found zero reinfections in a study of urban health care workers.((https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523483/))
  
 Majdoubi, Michalski et al demonstrated the existence of cross-reactive antibodies as far back as May 2020, and concluded that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2. This seroreactivity was evenly distributed across age and sex, correlated with circulating coronaviruses’ reactivity, and was partially outcompeted by soluble circulating coronaviruses’ spike.((Majdoubi, A., Michalski, C., O’Connell, S. E., Dada, S., Narpala, S. R., Gelinas, J. P., Mehta, D., Cheung, C., Winkler, D. F. H., Basappa, M., Liu, A. C., Görges, M., Barakauskas, V. E., Irvine, M. A., Mehalko, J., Esposito, D., Sekirov, I., Jassem, A. N., Goldfarb, D. M., & Pelech, S. (2021). //A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2.// JCI Insight. 2021;6(8):e146316. https://doi.org/10.1172/jci.insight.146316)) Majdoubi, Michalski et al demonstrated the existence of cross-reactive antibodies as far back as May 2020, and concluded that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2. This seroreactivity was evenly distributed across age and sex, correlated with circulating coronaviruses’ reactivity, and was partially outcompeted by soluble circulating coronaviruses’ spike.((Majdoubi, A., Michalski, C., O’Connell, S. E., Dada, S., Narpala, S. R., Gelinas, J. P., Mehta, D., Cheung, C., Winkler, D. F. H., Basappa, M., Liu, A. C., Görges, M., Barakauskas, V. E., Irvine, M. A., Mehalko, J., Esposito, D., Sekirov, I., Jassem, A. N., Goldfarb, D. M., & Pelech, S. (2021). //A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2.// JCI Insight. 2021;6(8):e146316. https://doi.org/10.1172/jci.insight.146316))
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 === Critique of Empirical Research === === Critique of Empirical Research ===
-Vaccine natural immunity getting little study attention by [[:public health]] authorities. https://www.wsj.com/articles/covid-19-coronavirus-breakthrough-vaccine-natural-immunity-cdc-fauci-biden-failure-11631548306+Vaccine natural immunity getting little study attention by [[:public health]] authorities.((https://www.wsj.com/articles/covid-19-coronavirus-breakthrough-vaccine-natural-immunity-cdc-fauci-biden-failure-11631548306))
  
 ==== Research Summaries ==== ==== Research Summaries ====
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   * [[https://www.nature.com/articles/s41586-021-03647-4|SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans]]   * [[https://www.nature.com/articles/s41586-021-03647-4|SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans]]
   * [[https://www.nature.com/articles/d41586-021-01442-9|Had COVID? You’ll probably make antibodies for a lifetime]]   * [[https://www.nature.com/articles/d41586-021-01442-9|Had COVID? You’ll probably make antibodies for a lifetime]]
 +  * [[https://www.espn.com/college-sports/story/_/id/33006959/ncaa-updates-covid-guidelines-winter-sports|On January 6, 2021]] the NCAA updated their Covid protocols and now consider student athletes to be "fully vaccinated" if they are within 90 days of a documented covid-19 infection.
 +  * [[https://apps.who.int/iris/rest/bitstreams/1346855/retrieve|The WHO Scientific Brief]] on natural immunity concludes that "Current evidence points to most individuals developing strong protective immune responses following natural infection with SARSCoV-2."
 +  * The EU Digital COVID Certificate [[https://ec.europa.eu/info/policies/justice-and-fundamental-rights/eu-citizenship/movement-and-residence/eu-digital-covid-certificate-vaccinations-and-travel-restrictions_en|recognizes]] natural immunity for 180 days. 
  
 ===== Propaganda ===== ===== Propaganda =====
  
 ==== CDC Propaganda ==== ==== CDC Propaganda ====
-The [[:Center for Disease Control and Prevention]] has abandoned all pretense that it is other than a [[:government]]-funded [[:public relations]] arm of the [[:pharmaceutical industry]] during the pandemic. The topic of natural immunity makes this reality most plain. +The [[:Center for Disease Control and Prevention]] has abandoned all pretense that it is other than a [[:government]]-funded [[:public relations]] arm of the [[:pharmaceutical industry]] during the pandemic. The topic of natural immunity makes this reality most plain.((https://www.cdc.gov/vaccines/covid-19/hcp/answering-questions.html))((https://www.healthline.com/health-news/people-whove-had-covid-19-should-still-get-vaccinated-heres-why))
-https://www.cdc.gov/vaccines/covid-19/hcp/answering-questions.html+
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