Table of Contents

Orwellian Science During the COVID-19 Pandemic

Let us call Orwellian Science that in which the research or reports state an opposite or disconnected conclusion with respect to the reported data.

Orwellian Published Science

April 2020 COVID-19 Defies ALL Rules of Virology

Received on 27 April 2020; received in revised form, 12 August 2020; accepted, 16 August 2020; published 01 September 2020

Dhadse et al., IJPSR, 2020; Vol. 11(9): 4104-4113. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 4104 IJPSR (2020), Volume 11, Issue 9

THE NOVEL CORONA VIRUS (nCoV2) SEEMS TO DEFY ALL LAWS OF VIROLOGY

P. V. Dhadse, Kiran Sethiya -, Chitrika Subhadarsanee and Khushboo Durge Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha - 442001, Maharashtra, India

ABSTRACT: Amongst the known coronaviruses, many were responsible for causing disease in humans knowingly from the common cold to acute severe respiratory syndrome. The novel coronavirus, nCoV-2 has been implied to cause increasingly severe damage to public health besides demolishing the global economy with a staggering figure of continuous rise in mortality within the afflicted cases in almost every country on this planet.

Owing to the perplexed scenario there are growing challenges involved in the containment of the spread of this novel coronavirus, which is mounting to be numerous and continuous. The battle is still on with this nCoV-2 since it has evolved, presenting with initial flu symptoms in patients affected to atypical pneumonia mimicking a catastrophic disseminated intravascular coagulation stage leading to cardio- respiratory abnormalities thus assuming proportions of mysterious illness to very unusual symptoms encountered in different age groups.

The genomic analysis of the nCoV-2 has revealed constant potential mutations with the evolution of different strains, thereby posing numerous challenges to develop an effective vaccine that will hold a promise on providing long term immunity to the host.

This review critically analyzes its arrival and spread across the globe to almost entire virology of this novel coronavirus to challenges that might be encountered in the future even if the vaccine is ready to combat the virus.

COVID-19 also resembles the same illness as affected by SARS -2003 virus 12. The first infection was unofficially reported from Wuhan city of China 13 have occurred on 17th November 2019. However, the official reported infection with first symptoms came from 4 workers within the same region of seafood wholesale market on 8th December, 2019.14

The mysterious illness was thought to have evolved from animals which had caused mutations in the virus to affect the humans and related with animal coronaviruses like SARS (2003) and the mortality rate was up to 10% for SARS CoV and up to 37% for MERS CoV 11, 15. It has turned out to be deadliest amongst the known coronaviruses affecting global population so far!

The COVID-19 virus appears to be fiercelyinfectious, dreadful as it is making the countries across the globe to count daily new infections and deaths and push the tolls.

This article reviews the entire virology of this novel coronavirus SARS-CoV-2; including its origin and arrival after mutation, how it is different from other coronaviruses, the possible mechanism of making their ways into the human cells along with other potential characteristics and possible ways which perhaps would help the research workers to develop the long term effective vaccine against COVID-19.

Tracking the “nCoV (SARS-CoV-2)”: Origin of COVID-19 Pandemic: How the Pandemic has Spread?)

The COVID-19 outbreak came without warning and spread like wildfire across the world by building a chain and clusters of transmission at different geographic locations.9)10)

1)
Lyu and Wehby | June 16, 2020 | Health Affairs | doi/10.1377/hlthaff.2020.00818
3)
Oct 4, 2021 | MedRxiv | 10.1101/2021.08.08.21261768v3
8)
April 25, 2022 | David N. Fisman et al | Canadian Medical Association Journal | Impact of population mixing between vaccinated and unvaccinated subpopulations on infectious disease dynamics: implications for SARS-CoV-2 transmission | DOI: https://doi.org/10.1503/cmaj.212105