====== Ophirex ======

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**Ophirex, Inc.** is an American public benefit pharmaceutical corporation based in Corte Madera, California.((//Ophirex funding and collaboration.// Ophirex | Lifesaving Antidotes. Retrieved April 13, 2022, from https://archive.ph/m8lOl)) ((//OPHIREX, INC.// Small Business Innovation Research (SBIR). Retrieved April 13, 2022, from https://archive.ph/d02vk)) Ophirex was founded by [[Matthew Lewin]] and [[Jerry Harrison]] in January 2015 to develop a rapid cure for [[snake venom]].((//Ophirex, Inc.// Gust. Retrieved April 13, 2022, from https://archive.ph/lenaT)) ((//Matthew Lewin.// LinkedIn. Retrieved April 13, 2022, from https://www.linkedin.com/in/matthew-lewin-37681b124/)) ((Lewin, M. (2017, August 28). //Ophirex Licenses Lilly - Shionogi Data for Novel Snakebite Treatment Development Program.// Bloomberg. https://archive.ph/5pvD3))

===== Affiliates =====

[[Derrick Rossi]], co-founder of [[pharmaceutical_companies:Moderna]], is an advisor to Ophirex.((Farooqui, S. (2021, July 6). //Moderna co-founder using mRNA technology to treat venomous snakebites.// Global News. https://archive.ph/URhV7))

==== Funding ====

Ophirex is funded by multiple awards from the [[:US Department of Defense]], a grant from [[:Wellcome Trust]], and the [[:World Health Organization]].((Rao, S. (2020, March 2). //Ophirex receives Wellcome Trust award to advance clinical development of novel snakebite treatment.// Business Wire. https://archive.ph/LHsYv)) ((Karon, P. (2020). //Snakebites are a deadly threat worldwide. Who’s behind the push for a new treatment?// Inside Philanthropy. https://web.archive.org/web/20220413132035/https://static1.squarespace.com/static/5eb10eb62bf19e1bbec031bc/t/60c38b9ca1a11d3f55c2fb7d/1623427997415/Inside+Philanthropy+2020-12-17+Snakebites.pdf)) ((//Broad Spectrum Envenomation Treatment.// SBIR. Retrieved April 16, 2022, from https://archive.ph/T9toA))
==== Staff ====

^ Name  ^ Position  ^
| Nancy Koch  | Chief Executive Officer((//Ophirex - Overview, News & Competitors.// ZoomInfo. Retrieved April 15, 2022, from https://web.archive.org/web/20220416034702/https://www.zoominfo.com/c/ophirex-inc/398629525))  |
| Rebecca Carter  | Vice President, Program Operations  |
| Kathleen Dotson  | Vice President, Finance  |
| Dana Miletic  | Operations Contracts Administrator  |
| Jack Tupman  | Executive  |
| [[Sunita Rao]]  | Senior Executive Administrator((//Sunita Rao.// LinkedIn. Retrieved April 15, 2022, from https://www.linkedin.com/in/sunitarao/))  |

===== Products =====

==== Antivenom ====

In August 2017, Ophirex licensed [[pharmaceutical_companies:varespladib]] from [[pharmaceutical_companies:Eli Lilly]] and [[pharmaceutical_companies:Shionogi]].((Lewin, M. (2017, August 28). //Ophirex Licenses Lilly - Shionogi Data for Novel Snakebite Treatment Development Program.// Bloomberg. https://archive.ph/5pvD3))

=== COVID-19 ===

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In 2020, Ophirex evaluated varespladib for treatment of [[:Acute Respiratory Distress Syndrome]] (ARDS), a common cause of death in [[:COVID-19]] patients. Despite the apparent winding down of the pandemic, their STAIRS trial continues.((Ophirex, Inc., & Premier Research International LLC. (2022, March 22). //A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Varespladib in Patients Hospitalized With Severe COVID 19 Caused by SARS-CoV-2.// ClinicalTrials.gov. https://archive.ph/jo7R9))

=== BRAVO Study ===

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Ophirex is running a clinical trial titled "Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite (BRAVO)" in collaboration with [[:Premier Research International]].((Ophirex, Inc., & Premier Research International LLC. (2022, February 9). //Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of a Multi-Dose Regimen of Oral Varespladib-Methyl in Subjects Bitten by Venomous Snakes.// ClinicalTrials.gov. https://archive.ph/xNuHy))

===== External links =====

  * [[https://wiki.whiteroseintelligence.com/en/Ophirex|White Rose Wiki]]