====== A-2021-000129 ======

**A-2021-000129** is the reference number for a [[completed FOI requests|completed FOI request]] from the [[:Public Health Agency of Canada]] (PHAC). It focuses primarily on a series of e-mail communications between PHAC employees in regards to how to handle communications around [[:ivermectin]] and public requests for its use to treat [[:COVID-19]].

===== Request details =====

^ Date  ^ Records Requested  ^ Request No.  ^ Response Letter  ^ Disclosure Package  ^ Notes  ^
| April 2022  | All communication regarding the use of [[:Ivermectin]] in the treatment of [[:Covid-19]]. Date range March 1, 2020 to June 7, 2021.  | A-2021-000129  | -  | [[https://ia601609.us.archive.org/34/items/release-package-phac-a-2021-000129-2022-04-12/ReleasePackage%20-%20PHAC-%20A-2021-000129%20-%202022-04-12.pdf|Disclosure]]  | -  |

==== People ====

The following table outlines the individuals involved in the discussions/materials included in the document release.

^ Name  ^ Affiliation  ^ Position  ^ Notes  ^
| [[:Kristian Andersen]]  | [[:Scripps Research Institute]]  | -  | -  |
| [[:Jacqueline Arthur]]  | [[:Public Health Agency of Canada]], [[:Centre for Communicable Disease and Infection Control]]  | Senior Manager, AMR Division  | On page 17 of the disclosure, she comments on the membership of the [[:Front Line COVID-19 Critical Care Alliance]] (FLCCC) saying, "Interesting membership, all white males..."  |
| [[:Mina Azad]]  | [[:Public Health Agency of Canada]], [[:Centre for Communicable Disease and Infection Control]]  | Research Analyst, COVID-19 Therapeutics  | PhD biochemist  |
| [[:Lizanne Beique]]  | [[:Public Health Agency of Canada]]  | Senior Policy Analyst  | -  |
| [[:Serena Cortés-Kaplan]]  | [[:Public Health Agency of Canada]], COVID-19 Therapeutics, [[:Centre for Communicable Disease and Infection Control]]  | Student Analyst  | -  |
| [[:Adéle Croteau]]  | [[:Public Health Agency of Canada]]  | Issues Manager - COVID-19 Therapeutics((Shared Services Canada. (2020, October 10). //Person Information - Adèle Crôteau - Issues Manager - COVID-19 Therapeutics.// Government of Canada. https://web.archive.org/web/20221007045418/https://geds-sage.gc.ca/en/GEDS/?pgid=015&dn=Q049QURFTEUuQ1JPVEVBVUBQSEFDLUFTUEMuR0MuQ0EsT1U9REdPLUJERyxPVT1DQ0RJQy1DTENNVEksT1U9SURQQ0ItREdQQ01JLE9VPVBIQUMtQVNQQyxPPUdDLEM9Q0E=))  | -  |
| [[:Jaahnavi Dave]]  | [[:Public Health Agency of Canada]]  | -  | Researcher under [[:BioCanRx]], a [[:pharmaceutical_companies:Pfizer]]-funded network. Also published research on a [[:COVID-19 vaccines|COVID-19 vaccine]] candidate while working with PHAC and early treatment denial. |
| [[:Joseph Djiometio]]  | [[:Public Health Agency of Canada]], [[:Centre for Communicable Disease and Infection Control]]  | Technical Lead, COVID-19 Therapeutics  | -  |
| [[:Laurent Duvernay-Tardif]]  | -  | -  | -  |
| [[:Bersabel Ephrem]]  | [[:Public Health Agency of Canada]], [[:Centre for Communicable Disease and Infection Control]]   | Director General  | -  |
| [[:Nicole Forbes]]  | [[:Public Health Agency of Canada]], [[:National Advisory Committee on Immunization]] (NACI), [[:Centre for Immunization Readiness]]((//Where Are They Now: Nicole Forbes.// (2020, November 20). BioCanRx. https://web.archive.org/web/20230316080334/https://biocanrx.com/now-nicole-forbes))  | Scientific Project Coordinator  | Alumni of [[:BioCanRx]]  |
| [[:Stephan Gadient]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Margaret Gale-Rowe]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Shalane Ha]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Emma Hodcroft]]  | [[:CoVariants]], [[:Institute of Social and Preventive Medicine]], [[:SIB Swiss Insitute of Bioinformatics]]  | -  | Signatory to the [[:John Snow Memorandum]]  |
| [[:Linsey Hollett]]  | [[:Health Canada]]  | -  | -  |
| [[:Kelly Hunt]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Marium Jamil]]  | [[:Public Health Agency of Canada]], Office of the Chief Science Officer  | Policy Analyst  | -  |
| [[:Anna Jirovec]]  | -  | -  | -  |
| [[:Marita Killen]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Pierre Kory]]  | [[:Front Line COVID-19 Critical Care Alliance]] (FLCCC)  | -  | Contacted [[:Andrew Morris]] to "spew anger" and advise Morris that he would be proven wrong about [[:ivermectin]].  |
| [[:Niyi Lawuyi]]  | [[:Public Health Agency of Canada]]  | COVID-19 Therapeutics Team, Advisor to Director General((Shared Services Canada. (2020, October 10). //Person Information - Niyi Lawuyi - Advisor to Director General.// Government of Canada. https://web.archive.org/web/20221007045431/https://geds-sage.gc.ca/en/GEDS/?pgid=015&dn=Q049TklZSS5MQVdVWUlAUEhBQy1BU1BDLkdDLkNBLE9VPURHTy1CREcsT1U9Q0NESUMtQ0xDTVRJLE9VPUlEUENCLURHUENNSSxPVT1QSEFDLUFTUEMsTz1HQyxDPUNB))  | -  |
| [[:Kaili Levesque]]  | [[:Health Canada]], [[:Public Health Agency of Canada]]  | Vice President, [[:COVID-19 vaccines|COVID-19 Vaccine]] Rollout  | -  | 
| [[:Erika Lingohr]]  | [[:Public Health Agency of Canada]]  | Researcher  | -  |
| [[:Syra Madad]]  | -  | -  | Developed a "cheat sheet" that included staying home, wearing a mask, [[:social distancing]], avoiding crowds, close contact or confined spaces, opening windows, washing hands, cleaning high-touch surfaces, complying with [[:contact tracing]], listening to [[:public health]] for updates, getting tested for [[:SARS-CoV-2]] periodically, getting transfected with a [[:COVID-19 vaccines|COVID-19 vaccine]], monitoring for symptoms of [[:COVID-19]], and covering coughs/sneezes.   |
| [[:Jonathan Mahdi]]  | [[:Health Canada]]  | -  | -  |
| [[:Cheryl Marisnky]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Hollie McLean]]  | [[:Health Canada]]  | -  | -  |
| [[:Andrew Morris]]  | [[:Ontario COVID-19 Science Advisory Table]], [[:University of Toronto]], [[:Sinai Health System]], [[:University Health Network]]  | -  | Writes "COVID Emails" newsletter. Chair of the Behavioural Science Working Group of the Ontario COVID-19 Science Advisory Table. Recommended his readers go outside and get sunlight.  |
| [[:Howard Njoo]]  | [[:Public Health Agency of Canada]]  | Deputy Chief Public Health Officer  | -  |
| [[:Pamela Ponic]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Celisse Poon Young]]  | [[:Public Health Agency of Canada]]  | Scheduling Assistant((//Celisse Poon Young · Public Health Agency of Canada · Scheduling Assistant.// OpenGovCA. Retrieved March 19, 2023, from https://web.archive.org/web/20230319202032/https://opengovca.com/employee/celisse-poon-young))  | -  |
| [[:Angela Rasmussen]]  | -  | -  | Developed a "cheat sheet" that included staying home, wearing a mask, [[:social distancing]], avoiding crowds, close contact or confined spaces, opening windows, washing hands, cleaning high-touch surfaces, complying with [[:contact tracing]], listening to [[:public health]] for updates, getting tested for [[:SARS-CoV-2]] periodically, getting transfected with a [[:COVID-19 vaccines|COVID-19 vaccine]], monitoring for symptoms of [[:COVID-19]], and covering coughs/sneezes.  |
| [[:Marina Salvadori]]  | [[:Public Health Agency of Canada]]  | -  | Briefs [[:Theresa Tam]] on "all things scientific"  |
| [[:Elaha Sarwar]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Jennifer Siushansian]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Theresa Tam]]  | [[:Public Health Agency of Canada]]  | Chief Public Health Officer  | -  |
| [[:Karen Timmerman]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| [[:Lisa Waddell]]  | [[:Public Health Agency of Canada]]  | -  | -  |
| Redacted  | [[:Alberta Health]]  | -  | -  |

==== Organizations ====

  * [[:AHS COVID-19 Scientific Advisory Group|Alberta COVID-19 Scientific Advisory Group]]
  * [[:Alberta Health Services]] (AHS)
  * [[:British Columbia COVID-19 Therapeutics Committee]]
  * [[:Canadian Agency for Drugs and Technologies in Health]] (CADTH)
  * [[:COVID-19 Clinical Pharmacology Task Group]]
  * [[:COVID-19 Therapeutics Task Force]]
  * [[:European Medicines Agency]] (EMA)
  * [[:Front Line COVID-19 Critical Care Alliance]] (FLCCC)
  * [[:Institut national d'excellence en santé et en services sociaux]] (INESSS)
  * [[:L·OVE]]
  * [[pharmaceutical_companies:Merck]]
  * [[:Ministry of Health of Peru]]
  * [[:National Institutes of Health]] (NIH)
  * [[:NIH COVID-19 Treatment Guidelines Panel]]
  * [[:Ontario COVID-19 Science Advisory Table]] (OST)
  * [[:Pan American Health Organization]] (PAHO)
  * [[:PHAC Emerging Science Group]]
  * [[:World Health Organization]] (WHO)

==== Therapeutics ====

^ Common name  ^ Brand name  ^ Other names  ^ Company  ^ Notes  ^
| [[:Anakinra]]  | Kineret  | -  | [[pharmaceutical_companies:Swedish Orphan Biovitrum]] (Sobi)  | -  |
| [[:Aspirin]]  | -  | -  | -  | -  |
| [[:Baricitinib]]  | Olumiant  | -  | [[pharmaceutical_companies:Incyte]], [[pharmaceutical_companies:Eli Lilly]] | -  |
| [[:Chloroquine]]  | -  | -  | -  | Not recommended in any context for [[:COVID-19]] by [[:Health Canada]]  |
| [[:Colchicine]]  | Colcrys, Mitigare, others  | -  | -  | -  |
| [[:Convalescent plasma]]  | -  | -  | -  | -  |
| [[:Dexamethasone]]  | -  | -  | -  | -  |
| [[:Fluvoxamine]]  | -  | -  | -  | -  |
| [[:Hydroxychloroquine]]  | -  | -  | -  | Not recommended in any context for [[:COVID-19]] by [[:Health Canada]]  |
| [[:Interferon]]  | -  | -  | -  | Not recommended in any context for [[:COVID-19]] by [[:Health Canada]]  |
| [[:Ivermectin]]  | Stromectol, Mectizan  | -  | [[pharmaceutical_companies:Merck]]  | Administered intravenously (IV) and orally in studies for the treatment of [[:COVID-19]]. Authorized by [[:Health Canada]] for the treatment of parasitic infections in humans and animals. Indicated in humans for the treatment of [[:intestinal strongyloidiasis]] and [[:onchoceriasis]]/rosacea. Not recommended for use outside of clinical trials.  |
| [[:Melatonin]]  | -  | -  | -  | -  |
| [[:Molnupiravir]]  | -  | MK-4482  | [[pharmaceutical_companies:Merck]], [[pharmaceutical_companies:Ridgeback Pharmaceuticals]]  | -  |
| [[:Lopinavir/ritonavir]]  | Kaletra  | -  | [[pharmaceutical_companies:AbbVie]]  | [[:HIV]]/[[:acquired_immune_deficiency_syndrome|AIDS]] drug  |
| [[:Quercetin]]  | -  | -  | -  | -  |
| [[:Remdesivir]]  | Veklury  | GS-5734  | [[pharmaceutical_companies:Gilead Sciences]]  | -  |
| [[:Vitamin C]]  | -  | Ascorbic acid, ascorbate  | -  | -  |
| [[:Vitamin D]]  | -  | -  | -  |
| [[:Zinc]]  | -  | -  | -  | -  |
^  [[:Monoclonal antibodies]]  ^^^^^
| [[:Tixagevimab/cilgavimab]]  | Evushield  | AZD7442  | [[pharmaceutical_companies:AstraZeneca]]  | -  |
| [[:Bamlanivimab]]  | -  | -  | [[pharmaceutical_companies:AbCellera]], [[pharmaceutical_companies:Eli Lilly]]  | -  |
| [[:Casirivimab]] and/or [[:imdevimab]]  | -  | -  | [[pharmaceutical_companies:Regeneron]], [[pharmaceutical_companies:Genentech]]  | -  |
| [[:Otilimab]]  | -  | -  | [[pharmaceutical_companies:GlaxoSmithKline]] | -  |
| [[:Sarilumab]]  | Kevzara  | -  | [[pharmaceutical_companies:Sanofi]], [[pharmaceutical_companies:Regeneron]]  | -  |
| [[:Tocilizumab]]  | Actemra  | -  | [[pharmaceutical_companies:Roche]]  | -  |

==== Protocols ====

  * [[:I-MASK+ Protocol]]

==== Clinical Trials ====

^ Trial Number  ^ Name  ^ Sponsor  ^ Principal Investigator  ^
| [[https://clinicaltrials.gov/ct2/show/NCT04527211|NCT04527211]]  | Effectiveness and Safety of Ivermectin for the Prevention of Covid-19 Infection in Colombian Health Personnel ([[:IveprofCovid19]])  | [[:Javeriana University]]  | [[:Eduar Echeverri]]  |
| [[https://clinicaltrials.gov/ct2/show/NCT04405843|NCT04405843]]  | Efficacy of Ivermectin in Adult Patients With Early Stages of COVID-19 ([[:EPIC Trial]])  | [[:Centro de Estudios en Infectogía Pediatrica]]  | [[:Eduardo López-Medina]]  |
| [[https://clinicaltrials.gov/ct2/show/NCT04529525|NCT04529525]]  | Ivermectin to Prevent Hospitalizations in COVID-19 ([[:IVERCORCOVID19]])  | [[:Instituto de Cardiología de Corrientes]]  | [[:Rodrigo Zoni]], [[:Julio Vallejos]]  |