====== Discovery of Medical Countermeasures Against Novel Entities ======

{{ ::domane.png?200|}}

**Discovery of Medical Countermeasures Against Novel Entities (DOMANE)** is a program of the [[Defense Threat Reduction Agency]] (DTRA) intended to rapidly identify drugs and compounds for repurposing against emerging pathogens.((Phillips, R., & Taylor, D. (2021, February 23). //A New DOMANE for the Pandemic Era.// DVIDS. http://archive.today/2022.03.12-032051/https://www.dvidshub.net/news/389661/new-domane-pandemic-era))

===== History =====

DOMANE was created in 2019.((Phillips, R., & Taylor, D. (2021, February 23). //A New DOMANE for the Pandemic Era.// DVIDS. http://archive.today/2022.03.12-032051/https://www.dvidshub.net/news/389661/new-domane-pandemic-era)) On December 11, 2019, the DTRA published a whitepaper outlining the project.((//Medical Futures Strategy: introducing DOMANE.// (2019, December 11). DVIDS. https://www.dvidshub.net/publication/issues/55976))

==== COVID-19 ====

In early 2020, [[Michael Callahan]] alerted his colleague [[Robert Malone]], then working as chief medical officer at [[pharmaceutical_companies:Alchem Laboratories]], of the emerging [[SARS-CoV-2]] outbreak in [[china:Wuhan]], [[China]]. Malone was also working on the DOMANE project, which identified several drugs approved by the [[Food and Drug Administration]] (FDA) that may work as potential treatments against [[COVID-19]], the disease thought to result from infection with the virus.((Borrell, B. (2020). //New York clinical trial quietly tests heartburn remedy against coronavirus.// Science. https://doi.org/10.1126/science.abc4739))

One of the first drugs identified was [[remdesivir]], an experimental product developed by [[pharmaceutical_companies:Gilead Sciences]] for use against [[Ebola]].((Gardner, D. (2021, February 4). //DTRA’s Therapeutic Arm Latches on to FDA-approved and Affordable Drugs for COVID-19 Relief.// Defense Visual Information Distribution Service. http://archive.today/2023.02.26-224227/https://www.dvidshub.net/news/388359/dtras-therapeutic-arm-latches-fda-approved-and-affordable-drugs-covid-19-relief))

Another candidate for repurposing was [[famotidine]], an anti-heartburn drug marketed in the [[United States]] by [[pharmaceutical_companies:Johnson & Johnson]] as Pepcid.((Halford, B. (2020, June 15). //Can Pepcid treat COVID-19?// Chemical & Engineering News. https://web.archive.org/web/20200711060533/https://cen.acs.org/pharmaceuticals/Pepcid-treat-COVID-19/98/i25)) ((Shoaibi, A., Fortin, S., Weinstein, R., Berlin, J. A., & Ryan, P. (2020). //Comparative Effectiveness of Famotidine in Hospitalized COVID-19 Patients.// medRxiv. https://doi.org/10.1101/2020.09.23.20199463)) On April 14, the [[Biomedical Advanced Research and Development Authority]] (BARDA) awarded Alchem a $20.7 million contract the conduct a clinical trial on the drug.

Other drugs identified were [[Celecoxib]], a drug sold by [[pharmaceutical_companies:Pfizer]] under the name Celebrex to treat [[arthritis]], and  Mectizan, [[pharmaceutical_companies:Merck]]'s brand of [[ivermectin]].((Gardner, D. (2021, February 4). //DTRA’s Therapeutic Arm Latches on to FDA-approved and Affordable Drugs for COVID-19 Relief.// Defense Visual Information Distribution Service. http://archive.today/2023.02.26-224227/https://www.dvidshub.net/news/388359/dtras-therapeutic-arm-latches-fda-approved-and-affordable-drugs-covid-19-relief))

DTRA also partnered with [[Quantum Leap Healthcare]] and [[Leidos]] to conduct clinical trials on various combinations of the repurposed drugs.

=== Treatment of Donald Trump ===

According to //[[Vanity Fair]]//, the DOMANE team made contact with White House physician [[Sean Conley]] in regards to the protocol used to treat President [[Donald Trump]] when he was diagnosed with [[COVID-19]].((Nast, C. (2020, October 5). //Quack Cures Lose Their Appeal Now That Trump Himself Is Sick With COVID-19.// Vanity Fair. http://archive.today/2023.03.28-002251/https://www.vanityfair.com/news/2020/10/quack-cures-lose-their-appeal-now-that-trump-himself-is-sick-with-covid-19))

DOMANE was featured in the January 2021 issue of //[[JSTO in the News]],// in which the program was described as using the [[COVID-19 pandemic]] as a "proof-of-concept" for future use in [[biodefense]].((Research and Development Directorate. (2021). //A New DOMANE: Biodefense in a Pandemic Era.// JSTO in the News, 11(1). https://www.dvidshub.net/publication/issues/57177)) It describes the use of "virtual clinical trials" involving [[wearable technology|wearables]], [[telehealth]], "e-consent", and electronic storage of patient information.

=== Robert Malone Denial of DOMANE Influence ===
Substack -  Puppet Masters of the Pandemic. Part 1: What Did The CIA Do in Wuhan?"
Part 1 of an interview with the New American Magazine
Robert W Malone MD, MS - Aug 3, 2023

By the way, the whole storyline that I was in charge of programs at DTRA is laughable. I was a small subcontractor with a DoD secret clearance. There's no way that a subcontractor would be given a programmatic authority over major biodefense programs such as DOMANE. So that's a whole false storyline that's been developed and repeatedly amplified by some of my detractors.

And yes, DOMANE did take credit for the development of Remdesivir because of what DTRA had done during the Ebola outbreak, working together with Michael Callahan. ((https://rwmalonemd.substack.com/p/puppet-masters-of-the-pandemic-part))

===== External links =====

  * [[https://sites.google.com/housatonicits.com/home0005/research/domane|Housatonic]]
  * [[https://www.whiteroseintelligence.com/discovery-of-medical-countermeasures-against-novel-entities/|White Rose Wiki]]
  * [[https://en.wikipedia.org/wiki/Defense_Threat_Reduction_Agency|Wikipedia - redirects to Defense Threat Reduction Agency]]
  * [[https://wikispooks.com/wiki/Defense_Threat_Reduction_Agency|Wikispooks (Defense Threat Reduction Agency)]]