====== Mechanisms of Injury (MOI) ======

In the Spring of 2021, Dr. [[:Sherri Tenpenny]] put together a detailed document of twenty mechanisms of injury (MOIs) by which the [[:Covid-19 vaccines]] might cause harm, or even death. The summary document(({{ :covid-19_vaccine_adverse_events_research:20_methods_of_injury_-_summary.pdf}})) lists them as follows;

  * MOI #1 – Injections can lead to death through anaphylactic shock, a life-threatening allergic reaction. With COVID shots, the allergic reaction is suspected to be caused by previous exposure to and sensitization to polyethylene glycol [PEG].
  * MOI #2 – Anti-Inflammatory macrophages, called M2, are inhibited by anti-spike-antibodies [anti-S-Ab].
  * MOI #3 – All COVID shots lead to the creation of a spike protein through a process called translation. The spike protein can damage the body by at least FOUR pathways:
  - The spike protein behaves as a hapten, a small molecule that binds to the surface of organs, leading to an autoimmune response.
  - The spike protein can damage organs directly by promoting cardiovascular complications, damaging blood vessels in the lungs, and breaking through the blood brain barrier (BBB), important for protecting the brain.
  - The spike protein can incorporate into human DNA through a process called transfection.
  - The spike protein evokes the release of destructive anti-spike-antibodies, [anti-S-Ab] discussed below.
  * MOI #4 – Spike protein can trigger changes in blood vessel walls, leading to pulmonary artery hypertension (PAH), which is fatal even under the best current conventional and alternative treatments.
  * MOI #5 – In men, the spike protein can bind to the ACE2 receptor on sperm. Risk of infertility is indicated but not yet proven.
  * MOI #6 – Spike proteins cause inflammation and disruption of the blood brain barrier (BBB), leading to neuropathology and brain degeneration.
  * MOI #7 – Neurological degeneration: spike proteins can damage the FUS gene and mutate the TDP-43 protein, leading to Amyotrophic Lateral Sclerosis (ALS).
  * MOI #8 – Neurological degeneration: mutation and altered function of the TDP-43 protein can also lead to frontotemporal lobe degeneration (FTLD), a cluster of chronic, degenerative neurological diseases.
  * MOI #9 – Mutation of the FUS gene can also lead to cancer.
  * MOI #10 – Adenoviruses used in both the Johnson & Johnson shot and the AstraZeneca shots pose a risk of cancer.
  * MOI #11 – Anti-spike-antibodies [anti-S-Ab] can cause significant damage, specifically to the lungs. The antibodies can also cross-react with 28 different human tissue types, establishing a mechanism for multisystem autoimmune disorders and multiorgan failure.
  * MOI #12 – Previous coronavirus exposure and the concept called ‘original antigenic sin’ stops true protection against the SARS-CoV2 if previously ill with a coronavirus infection.
  * MOI #13 – There is an increased risk of COVID illness and COVID-related death in persons who has been previously vaccinated with an influenza vaccine.
  * MOI #14 – The larger (highly elevated) SARS-CoV-2 antibody response from a COVID infection or from a COVID shot, results in prolonged and more severe illness.
  * MOI #15 – COVID shots can lead to enlarged lymph nodes that may have long term ramifications.
  * MOI #16 – Widespread use of COVID shots results in non-neutralizing antibodies, especially in people who have already had a COVID infection. This may be leading to virulent mutant viruses.
  * MOI #17 – Antibody Dependent Enhancement (ADE) is a phenomenon occurs when a person is exposed to a circulating coronavirus after being vaccinated. The anti-S-Ab enhances the entry of the SARS-CoV-2 virus into the cell (usually macrophages) and accelerates its replication, causing more severe illness than they would have experienced if they had not been vaccinated.
  * MOI #18 – Johnson/Johnson and AstraZeneca shots release a transgene that can lead to potentially deadly side effects from injecting raw genetic material that can induce anti-DNA antibodies and can integrate into human DNA.
  * MOI #19 – Both Johnson/Johnson and AstraZeneca shots carry a snip of double stranded DNA (dsDNA) [transgene] wrapped in an adenovirus outer “shell.” 50-billion particles are injected with each injection. dsDNA-antibodies are diagnostic of a long list of autoimmune disorders.
  * MOI #20: The AstraZeneca shot has been known to be associated with potentially deadly blood clots, a condition named Vaccine-Induced Prothrombotic Immune Thrombocytopenia (VIPIT).

The full document is also available.(({{ :covid-19_vaccine_adverse_events_research:20_methods_of_injury_-_full_ebook.pdf}}))

===== Antibody Epitopes =====
  * Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia((August, 2021 | Angela Huynh et al | [[:Nature]] | Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia | [[https://pubmed.ncbi.nlm.nih.gov/34233346/|DOI: 10.1038/s41586-021-03744-4]]))