====== ACTIV-6 ======

{{ ::activ-6_logo_.png?200|}}

**ACTIV-6**, officially **ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications**, is an American study of repurposed drugs to treat [[COVID-19]]. The four drugs included in the study are [[ivermectin]], [[fluvoxamine]], [[fluticasone]] and [[montelukast]]. 

It is part of the larger [[Accelerating COVID-19 Therapeutic Interventions and Vaccines]] (ACTIV) initiative.

The study officially began on June 8, 2021, and is scheduled for completion in March 2024.((Naggie, S., National Center for Advancing Translational Sciences (NCATS), & Vanderbilt University Medical Center. (2023, May 4). //ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications.// ClinicalTrials.gov. https://web.archive.org/web/20230518153157/https://clinicaltrials.gov/ct2/show/NCT04885530))

===== History =====

The study was first posted to [[ClinicalTrials.gov]] on May 13, 2021.((Naggie, S., National Center for Advancing Translational Sciences (NCATS), & Vanderbilt University Medical Center. (2023, May 4). //ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications.// ClinicalTrials.gov. https://web.archive.org/web/20230518153157/https://clinicaltrials.gov/ct2/show/NCT04885530))

===== Participants =====

ACTIV-6 is being led by principal investigators [[Susanna Naggie]] and [[Adrian Hernandez]] at the [[Duke Clinical Research Institute]].

==== Locations ====

Participating clinical trial sites include:

<WRAP column col4>
  * [[A New Start II]]
  * [[Advanced Medical Care]]
  * [[AMRON Vitality and Wellness Center]]
  * [[Ananda Medical Clinic]]
  * [[Arena Medical Group]]
  * [[Assuta Family Medical Group]]
  * [[Boston Medical Center]]
  * [[Chandler Regional Medical Center]]
  * [[Christ the King Health Care]]
  * [[CHRISTUS Saint Frances Cabrini Hospital]]
  * [[Christus St. Vincent Regional Medical Center]]
  * [[Clincept]]
  * [[Comprehensive Pain Management and Endocrinology]]
  * [[David Kavtaradze]]
  * [[Del Pilar Medical and Urgent Care]]
  * [[Doctors Medical Group of Colorado Springs]]
  * [[Elite Family Practice]]
  * [[Emory Healthcare]]
  * [[Essentia Health]]
  * [[Essential Medical Care]]
  * [[First Care Medical Clinic]]
  * [[Focus Clinical Research Solutions]]
  * [[Franciscan Health Michigan City]]
  * [[G&S Medical Associates]]
  * [[George Washington University Hospital]]
  * [[GFC of Southeastern Michigan]]
  * [[Health Quality Primary Care]]
  * [[Hoag Memorial Hospital Presbyterian]]
  * [[H.O.P.E. Clinical Research and Wellness]]
  * [[Innovation Clinical Trials]]
  * [[Jackson Memorial Hospital]]
  * [[Jadestone Clinical Research]]
  * [[JAX-ASCENT]]
  * [[Johns Hopkins Hospital]]
  * [[L&A Morales Healthcare]]
  * [[Lakeland Regional Medical Center]]
  * [[Lamb Health]]
  * [[Lice Source Services]]
  * [[Loyola University Medical Center]]
  * [[Lupus Foundation of Gainesville]]
  * [[Mediversity Healthcare]]
  * [[Miller Family Practice]]
  * [[Morehouse School of Medicine]]
  * [[NorthShore Medical Group]]
  * [[Ochsner Clinic Foundation]]
  * [[Olive View-UCLA Medical Center]]
  * [[Olivo Wellness Medical Center]]
  * [[Pine Ridge Family Medicine]]
  * [[Premier Health]]
  * [[Raritan Bay Primary Care & Cardiology Associates]]
  * [[Romancare Health Services]]
  * [[Rush University Medical Center]]
  * [[Stanford University]]
  * [[Sunshine Walk-In Clinic]]	
  * [[Tabitha B. Fortt]]
  * [[Tallahassee Memorial Hospital]]
  * [[Tampa General Hospital]]
  * [[The Angel Medical Research Corporation]]
  * [[Trident Health Center]]
  * [[UF Health – Precision Health Research Center]]
  * [[University Medical Center New Orleans]]
  * [[University of Arkansas for Medical Sciences]]
  * [[University of Florida Health]]
  * [[University of Kansas School of Medicine-Wichita]]
  * [[University of Massachusetts Medical School]]
  * [[University of Miami]]
  * [[University of Minnesota]]
  * [[University of Missouri]]
  * [[Well Pharma Medical Research]]
</WRAP>

==== Funding ====

ACTIV-6 is funded by:((Naggie, S., Boulware, D. R., Lindsell, C. J., Stewart, T. G., Slandzicki, A. J., Lim, S. C., Cohen, J., Kavtaradze, D., Amon, A. P., Gabriel, A., Gentile, N., Felker, G. M., Jayaweera, D., McCarthy, M. W., Sulkowski, M., Rothman, R. L., Wilson, S., DeLong, A., Remaly, A., & Wilder, R. (2023). //Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial.// JAMA. https://doi.org/10.1001/jama.2023.1650))

  * [[Biomedical Advanced Research and Development Authority]] (BARDA)
  * [[National Center for Advancing Translational Sciences]] (NCATS)
  * [[Office of the Assistant Secretary for Preparedness and Response]]
  * [[Vanderbilt University Medical Center]]

===== External links =====

  * [[https://clinicaltrials.gov/ct2/show/NCT04885530|ClinicalTrials.gov]]
  * [[https://activ6study.org/|Website]]