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--- pharmaceutical_companies:providence_therapeutics [2022/07/12 03:38]
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+++ pharmaceutical_companies:providence_therapeutics [2023/05/11 07:12] (current)
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-**Providence Therapeutics** is a [[:canada|Canadian]] [[:biotechnology|biotechnology]] company based in [[:canada:alberta:Calgary]], [[:canada:Alberta]], with additional operations in [[:canada:Ontario:Toronto]], [[:canada:Ontario]]. The company specializes in messenger RNA (mRNA) vaccines.((//About Providence Therapeutics.// (2022). Providence Therapeutics. https://web.archive.org/web/20220711155818/https://providencetherapeutics.com/about.html))
+**Providence Therapeutics Holdings Inc.** is a [[:canada|Canadian]] [[:biotechnology|biotechnology]] company based in [[:canada:alberta:Calgary]], [[:canada:Alberta]], with additional operations in [[:canada:Ontario:Toronto]], [[:canada:Ontario]]. The company specializes in messenger RNA (mRNA) vaccines.((//About Providence Therapeutics.// (2022). Providence Therapeutics. https://web.archive.org/web/20220711155818/https://providencetherapeutics.com/about.html))
 ===== History =====
+Providence was founded in 2015 in order to develop [[:vaccines]] targeting [[:cancer]].
 ==== COVID-19 ====
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 One year later in April 2021, Providence founder [[:Brad Sorenson]] announced he was fed up with the lack of support from the Canadian government and would be relocating operations overseas.((Tasker, J. P. (2021, April 30). //COVID-19 vaccine maker Providence says it’s leaving Canada after calls for more federal support go unanswered.// CBC News. https://web.archive.org/web/20220711165025/https://www.cbc.ca/news/politics/providence-therapeutics-pulling-out-canada-1.6009068))
+On September 13, 2021, Providence announced that it had entered into two separate contracts with [[:Everest Medicines]] to license rights to their mRNA COVID-19 vaccine candidates to markets in [[:China]], Southeast [[:Asia]] and [[:Pakistan]], and to establish a broader global partnership around the mRNA platform.((Forester, N., Wong, N., Robinson, D., & Lococo, E. (2021, September 13). //Providence Therapeutics Enters into Comprehensive Agreements with Everest Medicines to Advance mRNA Vaccines and Therapies, including COVID-19 Vaccines, in Emerging Markets in Asia.// Providence Therapeutics. https://providencetherapeutics.com/press-details/providence-therapeutics-enters-into-comprehensive-agreements-with-everest-medicines-to-advance-mrna-vaccines-and-therapies-including-covid-19-vaccines-in-emerging-markets-in-asia.html))
 ===== Affiliations =====
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 | [[:Eric Marcusson]]  | Co-founder & board member  | [[Isis Pharmaceuticals]], [[Regulus Therapeutics]]  |
 | [[:Donna T. Ward]]  | Board member  | [[Ionis Pharmaceuticals]], [[Alnylam Pharmaceuticals]], [[:DT Ward, PC]]  |
-| [[:Pam Ohashi]]  | Scientific Advisory Board chair  | [[:University of Toronto]], [[:Canada Research Chair]], [[:Princess Margaret Cancer Centre]], [[:American Association for Cancer Research]]  |
+| [[:Pamela Ohashi]]  | Scientific Advisory Board chair  | [[:University of Toronto]], [[:Canada Research Chair]], [[:Princess Margaret Cancer Centre]], [[:American Association for Cancer Research]]  |
 | [[:Brian Barber]]  | Scientific Advisory Board member  | [[:University of Toronto]], [[:University Health Network]], [[Sanofi Pasteur]], [[Mojave Therapeutics]]  |
 | [[:Art Krieg]]  | Scientific Advisory Board member  | [[Translate Bio]], [[Checkmate Pharmaceuticals]], [[Coley Pharmaceuticals]], [[Sarepta Pharmaceuticals]], [[Pfizer]], [[:Atlas Ventures]], [[:RNA Therapeutics Institute]] at the [[:University of Massachusetts]], [[:Oligonucleotide Therapy Society]]  |
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 ==== Funding ====
+Pre-clinical trials for PTX-COVID19-B were funded by the [[:National Research Council of Canada]], the [[:Canadian Institutes of Health Research]] (CIHR), [[:Ontario HIV Treatment Network]], [[:Li Ka Shing Knowledge Institute]], and the [[:Juan and Stefania Speck]] fund for COVID-19 and other virus infections.((Liu, J., Budylowski, P., Samson, R., Griffin, B. D., Babuadze, G., Rathod, B., Colwill, K., Abioye, J. A., Schwartz, J. A., Law, R., Yip, L., Ahn, S. K., Chau, S., Naghibosadat, M., Arita, Y., Hu, Q., Yue, F. Y., Banerjee, A., Hardy, W. R., & Mossman, K. (2022). //Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B.// Science Advances, 8(3). https://doi.org/10.1126/sciadv.abj9815))
 Providence received a $5 million grant from the [[:National Research Council of Canada]] in 2021, though the majority of its funding has been private.((Villani, M. (2021, February 2). //Providence Therapeutics seeking federal support for “made-in-Canada” COVID-19 vaccine.// CTV News Calgary. https://calgary.ctvnews.ca/providence-therapeutics-seeking-federal-support-for-made-in-canada-covid-19-vaccine-1.5292681)) Founder Brad Sorenson alleged at the time to have already spent $10 million in their COVID-19 vaccine development.
 In November 2021, the [[:Bill & Melinda Gates Foundation]] gave $2,118,334 to Providence Therapeutics to develop more cost-effective [[:mrna vaccines|mRNA vaccines]].((//Providence Therapeutics.// (2021, November). Bill & Melinda Gates Foundation. https://archive.ph/f8CM8))
+===== Patents =====
+Providence's COVID-19 vaccine is based on patent CA3096009, filed October 9, 2020.((Liu, J., Budylowski, P., Samson, R., Griffin, B. D., Babuadze, G., Rathod, B., Colwill, K., Abioye, J. A., Schwartz, J. A., Law, R., Yip, L., Ahn, S. K., Chau, S., Naghibosadat, M., Arita, Y., Hu, Q., Yue, F. Y., Banerjee, A., Hardy, W. R., & Mossman, K. (2022). //Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B.// Science Advances, 8(3). https://doi.org/10.1126/sciadv.abj9815)) Listed inventors are [[:Eric Marcusson]], [[:Jumai Aeola Abioye]], and [[:Natalia Martin Orozco]].((//CA3107232 Compositions and methods for the prevention and/or treatment of COVID-19.// (2022, April 9). World Intellectual Property Organization. https://archive.ph/bUGh3#selection-2107.0-2107.14))
 ===== Rumours =====
 On February 13, 2022, an article was published on [[:Substack]] that claimed Canadian Prime Minister [[:Justin Trudeau]] was a former or current owner of Providence, and as such, had profited greatly from the worldwide use of [[:COVID-19 vaccines]].((bilbobitch. (2022, February 13). //Trudeau Recently Sold the mRNA Patents to China for $500M USD - Trudeau may have won the lottery.// Bilbobitch’s Newsletter; Substack. https://bilbobitch.substack.com/p/trudeau-recently-sold-the-mrna-patents)) The article alleged that Providence-related patents owned by the [[:University of British Columbia]] (UBC) had been transferred into Trudeau's name (with the help of [[:Klaus Schwab]] and [[:Bill Gates]]), subsequently licensed to [[Moderna]] and [[Pfizer]], and then sold to [[Everest Medicines]] in [[:China]].