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--- mrna_vaccines [2022/02/07 20:16]
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+++ mrna_vaccines [2022/10/27 20:22] (current)
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 In a nutshell, in this article, what they found was that the BNT162b2 (Pfizer/BioNTech) injectable products are modulating the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli whereby the response of innate immune cells to TLR4 and TLR7/8 ligands was weaker after BNT162b2 injection, while fungi-induced cytokine responses were stronger.((https://jessicar.substack.com/p/the-bnt162b2-mrna-vaccine-against))
 {{ : adaptive_vs_innate_immunity.png}}
+==== Differences for non-amplifying mRNA and self-amplifying mRNA Vaccines =====
+{{ ::nucleic_acid_vaccines_in_the_prevention_and_treatment_of_infectious_diseases_and_cancers.png?600|}}
+Front. Cell Dev. Biol., 25 May 2021 | https://doi.org/10.3389/fcell.2021.633776
+A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications
+Figure 2. The structure and mechanism of action of mRNA vaccines. (1) There are two widely acknowledged types of mRNA vaccines, namely non-amplifying mRNA and self-amplifying mRNA.
+The typical components of the two mRNAs are: the cap, untranslated regions (UTRs) of 5′ and 3′, an open reading frame (ORF, including GOI) encoding the antigen, and Poly(A)n tail.
+Compared to non-amplifying mRNA, the size of self-amplifying mRNAs is fairly larger than non-amplifying mRNAs.
+For example, in α-virus-based replicons, the extra length comes from a large ORF encoding four non-structural proteins (nsP1-4). (2) In vivo transcribed mRNA (IVT mRNA) is obtained from a DNA template in a cell-free system.
+The IVT mRNA is transfected into dendritic cells (DC) by endocytosis. The mRNA is translated into antigenic proteins by utilizing a ribosome translation mechanism.
+The post-translational antigen protein undergoes post-translational modification and can play a role in the cells it produces. The antigen protein is degraded by the proteasome in the cytoplasm.
+The resulting antigen peptide is loaded onto the MHC molecule. The loaded peptide-MHC epitope complex appears on the cell surface, and after T cell receptor recognition and appropriate co-stimulation, an antigen-specific CD8+ T cell response is eventually induced. ((https://web.archive.org/web/20210525182332/https://www.frontiersin.org/articles/10.3389/fcell.2021.633776/full)) {{ ::mrna_vaccines_diagram.png?1200|}}
+Image non-amplifying mRNA and self-amplifying mRNA Vaccines ((https://web.archive.org/web/20220826180443/https://www.frontiersin.org/files/Articles/633776/fcell-09-633776-HTML/image_m/fcell-09-633776-g002.jpg))
 ===== History of mRNA Vaccine =====
+mRNA Vaccines: The CIA and National Defense
+This isn't going to end well.
+Substack Robert W Malone MD, MS - October 27, 2022
+Transcript of the video above
+=== mRNA Vaccines: Fact Versus Fiction. ===
+My purpose is not to overwhelm you with all of the various clips, newspaper clippings, scientific journal articles, et cetera, et cetera, but rather to help you to comprehend the technology and why it's being pushed and how it's being pushed. I'm going to present this as being focused on comprehension, not politics.
+Now that may elicit some, "Oh, you're just controlled opposition." That seems to be a favorite theme that's hitting me and [[:Jordan Peterson]] and [[:Peter McCullough]] and a number of others, which is extremely divisive right now and isn't helping any of us. But just to set the record straight, two months ago in the Global COVID Summit Declaration IV we made unequivocal statements about the need to prosecute, that the need for accountability is there, that the vaccine should be stopped. They're neither saved nor effective, et cetera. I just want to make it clear that I put out, and my colleagues in [[:Global COVID Summit]] and the [[:International Alliance of Physicians and Medical Scientists]] have been very clear about our position regarding these products. I won't call them vaccines. I think that's really not an appropriate term given their activity, but that's not my purpose here. I'm hoping that by, if I can make the slides work, there we go, that by the time we're through with this, you'll kind of understand these core things. What are the drivers of COVID crisis response and the multiple truths behind them?
+Looking at understanding the RNA technology as a way to start to make sense out of what we've all experienced. Paul has just given you another lens that through which you can view what has occurred. There are many others. He, for instance, just barely touched on the World Economic Forum and the [[:World Health Organization]], the collusion with the UN, et cetera. He hasn't really talked about the [[:Bill & Melinda Gates Foundation]] initiatives. There is so many different ways that we can understand and begin to process what we've experienced over the last two and a half years. I speak about those various ways in different forums. But this one, I'm just going to focus on the RNA tech. It's enough to handle that in the time we have here.
+What was the unmet medical need that was being addressed? I think it's important for us to understand at least those points of view of the other side that are comprehensible. There are clearly aspects that are nefarious, but I want you to understand at least some of the underlying rationale. Understand genetic vaccine technology, including mRNA. What is really the tech? It has been presented to a lot of people as a black box. It has this acronym that seems very intimidating to many people. I hope that when you leave here, you'll feel that you have a good grasp of what the technology is, what its fundamentals are so that you can process information and read the papers and make your own decisions about what you think things mean.
+I want you to understand the difference between the payload and the platform. We're talking about the fundamentals of the [[:pharmacology]] of this product category. I want you to understand how and why it's being pushed. This is more about me trying to give you insight and understanding about what is going on here as seen through this one lens of the [[:mRNA technology]] and the falsehoods and truths that are behind it. It is only one of many lenses. I've spoken about mass formation. I've spoken about the [[:World Economic Forum]]. I've spoken about the administrative state. There's so many variables going on here that we could talk for eight hours, but I'm just going to focus on the RNA.
+Why [[:mRNA vaccines]]? Why is this being pushed? (more)
+=== Bio-warfare or Bio-defense ===
+The truth is that [[:DARPA]], which is the operational development arm, basically the CIA, fell in love with the RNA technology over a decade ago. They decided to capitalize it and force it into the market space. For instance, they're the ones that have capitalized through [[:In-Q-Tel]], their investment arm, the new RNA manufacturing facilities up in Canada. This is a [[:CIA]] program. There's no ambiguity here. I'm not telling state secrets.
+The **technology was basically pulled out of the trash can**, because it had been suppressed by [[:Merck]] after I developed it over 30 years ago. Then it was advanced very aggressively by DARPA. DARPA funded and basically built [[:Moderna]]. They're continuing to push all this. They're pushing it through the government. What you're seeing is the power of the intelligence community and the new bio-defense industrial complex that's developed since the anthrax attacks and it really goes beyond that in being able to push their agenda through the government.
+When you see all these circumventing of normal procedures and rules, that's happening because largely our intelligence community is pushing that through the administrative state structure. Why are they doing it?
+=== How mRNA Does & Doesn't Work ===
+The problem is like everything, it all sounds great on paper, and then, you got to make it work, and you got to deal with the consequences when things don't go right. I just wanted you to understand that. The logic for why mRNA was because mRNA typically only lasts for a few hours or maybe half a day after it's manufactured in your body. The idea that I had way back then was that this RNA could be used like a drug, administered, and that if somebody has a toxicity, a toxic reaction, it'll be degraded and gone. Just like you clear most drugs. And then, a physician can decide, let's not do that again. That was the idea behind RNA as opposed to DNA, which sticks around for a long, long time in your body once it's in a cell. That's where this started from.
+Now, let's talk about, remember, my goal is that you walk out of this understanding. This is not a focus on passing judgment. This is a focus on empowering you to comprehend what's going on. And the starting point is you have to understand that DNA makes RNA, and RNA makes protein. Not everybody has been through modern biology and understands the central dogma, but that's where this is going. mRNA is one of many different types of RNA. It's an acronym. It sounds scary to some people. It means messenger RNA. There's other kinds of RNA. [[:Ribosomal RNA]], [[:transfer RNA]]. They do different things. RNA is just a molecule, a polymer that your body uses for many different things.
+And one of them is to transfer information from DNA to the protein manufacturing machinery. And so, the idea of using mRNA as a drug is basically like hijacking the normal apparatus. If you think of RNA like a ticker tape to tell the little machine that makes protein what to make, you're taking and sticking in a foreign molecule, a foreign RNA that's not made from a copy of your DNA, and that's going to make the protein manufacturing machinery make a different protein, protein from a virus. I just wanted you to understand that. And this is just a diagram of those different types of RNAs and the machinery. We don't need to go into the molecular biology of it.
+And we all know this virus now. Everybody's become a [[:virologist]] and an [[:epidemiologist]] over the last three years. And the spike protein on the right, as you can see, has kind of two parts. One is a part that sticks into the cell. ((https://rwmalonemd.substack.com/p/mrna-vaccines-the-cia-and-national))
+===== Genetic Modification =====
+During the rollout of the COVID-19 mRNA [[quasi-vaccines]], there was heated debate over whether or not genetic code from the quasi-vaccines could be integrated into the human genome. Researchers have noted potential mechanisms for how this could occur.((September 1, 2022 | Anthony M Kyriakopoulos et al. | preprint | Potential Mechanisms for Human Genome Integration of Genetic Code from SARS-CoV-2 mRNA Vaccination | [[https://www.authorea.com/users/455597/articles/584039-potential-mechanisms-for-human-genome-integration-of-genetic-code-from-sars-cov-2-mrna-vaccination|DOI: 10.22541/au.166203678.82079667/v1]]))