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julie_ledgerwood [2022/01/02 17:21]
leonardo [Claims about Covid Vaccines]
julie_ledgerwood [2022/01/02 18:37] (current)
leonardo
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 ===== Claims about Covid Vaccines ===== ===== Claims about Covid Vaccines =====
  
-These claims were made during an NIH  panel discussion on the Ethics of Vaccine Mandates ((https://videocast.nih.gov/watch=44165)).+Julie Ledgerwood made these claims during an NIH  panel discussion on the Ethics of Vaccine Mandates ((https://videocast.nih.gov/watch=44165)):
  
- +  That she has no conflict of interest to disclose. 
-  No conflict of interest to disclose. +    * Yet, a slide in the presentation reads"**The VRC/NIAID has a research collaboration agreement with Moderna to study COVID vaccines.**" 
-    * Slide shows: The VRC/NIAID has a research collaboration agreement with Moderna to study COVID vaccines. +  * She claims the Pfizer efficacy is as follows:
-  * Pfizer efficacy:+
  
 ^ Age    ^ Efficacy  ^ Reference  ^ ^ Age    ^ Efficacy  ^ Reference  ^
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 | 5-11         91% | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2116298|Walter et al. NEJM online Nov.9, 2021   ]] | | 5-11         91% | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2116298|Walter et al. NEJM online Nov.9, 2021   ]] |
  
-  * Moderna efficacy:+  * She claims the Moderna efficacy is as follows:
  
 ^ Age    ^ Efficacy  ^ Reference  ^ ^ Age    ^ Efficacy  ^ Reference  ^
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 | 12-17  |  100% | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2109522|Ali et al. NEJM online Aug. 11, 2021 ]] | | 12-17  |  100% | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2109522|Ali et al. NEJM online Aug. 11, 2021 ]] |
  
-  * Janssen efficacy:+  * She claims the Janssen efficacy is as follows:
  
 ^ Age    ^ Efficacy  ^ Reference  ^ ^ Age    ^ Efficacy  ^ Reference  ^
 | 18+    |       66% (85% severe disease) | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2101544|Sadoff et al. NEJM 384:2187, 2021]] | | 18+    |       66% (85% severe disease) | [[https://www.nejm.org/doi/full/10.1056/NEJMoa2101544|Sadoff et al. NEJM 384:2187, 2021]] |
  
- +  She presents the following slides as evidence for "Real world" effectiveness of the vaccines, claiming they confirm vaccine effectiveness over 90%:
-  *"Real world" effectiveness:+
     * [[https://www.nejm.org/doi/full/10.1056/NEJMc2102153|NEJM 384:1962, 2021]]     * [[https://www.nejm.org/doi/full/10.1056/NEJMc2102153|NEJM 384:1962, 2021]]
     * [[https://www.cdc.gov/mmwr/volumes/70/wr/mm7013e3.htm|CDC MMWR Weekly / April 2, 2021]]     * [[https://www.cdc.gov/mmwr/volumes/70/wr/mm7013e3.htm|CDC MMWR Weekly / April 2, 2021]]
-  * Studies confirmed vaccine effectiveness over 90% +  * She claims vaccines are typically monitored for safety by VAERS 
-  * Vaccines are typically monitored for safety by VAERS +    She claims additional monitoring systems are in place, where a slide shows: v-safe, VSD and CISA. 
-  Slide: v-safe, VSDCISA (as additional monitoring systems) +  * She claims there is an unprecedented, multi-layer levels of vaccine safety surveillance for Covid vaccines
-  * Unprecedented, multi-layer levels of vaccine safety surveillance. +  * On Adverse Events, she claims ((https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/adverse-events.html))
-  * Adverse events: +    * Anaphylaxis: happens in 2 to 5 people per million vaccinated. She claims it is similar to other vaccines.
-    * Anaphylaxis: 2 to 5 people per million vaccinated. Similar to other vaccines.+
     * TTS: CDC and FDA monitoring and watching, lot of research going into why this is happening.      * TTS: CDC and FDA monitoring and watching, lot of research going into why this is happening. 
-      *  It has impacted how the Janssen vaccine is used, and alerted the population to watch for these symptoms. +      * She claims it has impacted how the Janssen vaccine is used, and alerted the population to watch for these symptoms. 
-      * 54 reports confirmed after 16.4 million doses of Janssen. +      * Her slides claim 54 reports of TTS were confirmed after 16.4 million doses of Janssen. 
-      * 2 reports confirmed after 437 million doses of Moderna. +      * Her slides claim 2 reports of TTS were confirmed after 437 million doses of Moderna. 
-      * Slide: Based on available data, there is not an increased risk for TTS after mRNA Covid-19 vaccination.    +      * Her slides claim that, based on available data, there is not an increased risk for TTS after mRNA Covid-19 vaccination.    
     * Myo/pericarditis:     * Myo/pericarditis:
-      * About half of VAERS reports seem to be valid reports that might be vaccine related, which have to be further evaluated for severity and outcome. +      * She claims about half of VAERS reports seem to be valid reports that might be vaccine related, which have to be further evaluated for severity and outcome. 
-      * Most seen in younger males, and generally self limited.   +      * She claims this reaction is most seen in younger males, and generally self limited.   
-      * This has been considered thoroughly by the FDA and CDC advisory panels in their Risk Benefit Analysis. +      * She claims this has been considered thoroughly by the FDA and CDC advisory panels in their Risk Benefit Analysis. 
-        * (this analysis?https://web.archive.org/web/20211026200013/https://www.fda.gov/media/153507/download +        * It isn't clear to which Risk Benefit Analysis she refers. Could be this one: https://web.archive.org/web/20211026200013/https://www.fda.gov/media/153507/download 
-      * They looked at the risks mentioned above, and the risks of covid to applicable populations, and determined that the benefits of the vaccine far outweigh the risks. +      * She claims the FDA and CDC looked at the risks mentioned above, and the risks of Covid to applicable populations, and determined that the benefits of the vaccine far outweigh the risks. 
-      * This also allowed us to understand how Covid causes myo/pericarditis. +      * She claims this also allowed us to understand how Covid causes myo/pericarditis. 
-    * Sources: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/adverse-events.html +  * She claims the CDC also looked at all cause of death among vaccinated vs. unvaccinated. 
-  * The CDC also looked at all cause of death among vaccinated vs. unvaccinated. +    * She claims vaccinated people have lower rate of deaths, according to a study of 11 million people ((https://www.cdc.gov/mmwr/volumes/70/wr/mm7043e2.htm)). 
-    * https://www.cdc.gov/mmwr/volumes/70/wr/mm7043e2.htm +  * She claims 1000 people are dying of Covid every day in the USA, largely the unvaccinated. 
-    * Vaccinated people have lower rate of deaths (study of 11 million people+  * She claims unvaccinated people have a tenfold greater risk of death than vaccinated. 
-  * 1000 people dying of Covid every day in the USA. Largely the unvaccinated. +    * She claims this is backed by multiple assessments in multiple states and countries. 
-  * Unvaccinated have a tenfold greater risk of death than vaccinated  +  * She claims the death rate increased by 15.9% during the pandemic, and that life expectancy has been decreased. 
-    * Multiple assessments in multiple states and countries. +  * She claims Covid is the 3rd leading cause of death in the USA, after heart disease and cancer. 
-  * Death rate increased by 15.9% during the pandemic. Life expectancy has been decreased. +  * She claims there were **more deaths by Covid in 2021 than in 2020**
-  * Covid is the 3rd leading cause of death in the USA, after heart disease and cancer. +  * She claims the data consistently shows case, hospitalization and death rates are far higher in unvaccinated. 
-  * More deaths by Covid in 2021 than in 2020. +    * She claims the risk of death among unvaccinated is 14X higher than among vaccinated. 
-  * Consistent datacase, hospitalization and death rates are far higher in unvaccinated. +    * She claims this data has been replicated and shown consistently. 
-    * Risk of death among unvaccinated 14X than vaccinated. +    * She claims **vaccinated people are not occupying health care facilities**
-    * This data has been replicated and shown consistently. +    * She claims that, in Texas, unvaccinated people were 20X more likely to die than fully vaccinated. 
-    * Vaccinated people are not occupying health care facilities. +  * She stated that **vaccinations that occur in one month intervals are priming series**. It wasn't quite clear why she said that in the context. 
-    * In Texas, unvaccinated were 20X more likely to die than fully vaccinated. +  * She claims that, in a 2-month interim analysis((https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-11-19/02-COVID-Perez-508.pdf)), efficacy against symptomatic Covid-19 in boosted group was 95.6%. 
-  * Booster study: https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-11-19/02-COVID-Perez-508.pdf +  * She claims this was also corroborated by Israel data. 
-  * Vaccinations that occur in one month intervals are priming series. +  * In Summary: She claims Covid vaccines are **safe and effective**.
-  * In a 2-month interim analysis, efficacy against symptomatic Covid-19 in boosted group was 95.6% +
-  * Also corroborated by Israel data. +
-  * In Summary: Covid vaccines are safe and effective.+
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