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--- covid-19_vaccines:adverse_events:myocarditis [2022/01/22 22:39]
robin [Peer-Reviewed Scientific papers regarding COVID-19 Vaccine Associated Myocarditis]
+++ covid-19_vaccines:adverse_events:myocarditis [2022/07/15 06:21] (current)
liam
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 ====== COVID-19 Vaccine Associated Myocarditis ======
 During the experimental [[:COVID-19 vaccines]] campaign, many vaccine recipients have suffered vaccine-associated [[:myocarditis]]. There is a debate over the nature of the damage caused in these cases of myocarditis as well as the relative risk of myocarditis associated with [[:SARS-CoV-2]] infection or [[:COVID-19]] cases.
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 ===== Research =====
 Increased occurrence of myocarditis, pericarditis and myopericarditis has been associated with Covid-19 inoculations,((https://www.nature.com/articles/s41591-021-01630-0)) along with Covid-19 infection.
 {{ :myocarditis_vaers.jpg?600 |}}
+^             Incidence of Myocarditis Following the Second Dose of a Covid-19 mRNA Vaccine               ^^^^^^^^^
+^  ^  Male: Age 12-15  ^  Male: Age 12-17  ^   Male: Age 16-17  ^   Male: Age 16-19  ^   Male: Age 18-24  ^  Male: Age < 30  ^  Male: Age < 40  ^  Rate from Sars-cov-2  ^
+| Kaiser Permanente Study - Dec 27, 2021((https://www.medrxiv.org/content/10.1101/2021.12.21.21268209v1))|  -  |  1 / 1860   |  1 / 2650    |
+| Nature Medicine Paper - Dec 25, 2021((https://www.medrxiv.org/content/10.1101/2021.12.23.21268276v1))|  -  |   |  -  |  101 excess events per million (Moderna)  |   30 excess events per million  |
+| USA FDA ACIP Meeting Presentation((http://dx.doi.org/10.15585/mmwr.mm7027e2)) |  |   |  62.8 per million  |   |  50.5 per million  |
+| Israel MoH((https://www.nejm.org/doi/full/10.1056/NEJMc2116999?query=featured_home)) |  1 / 12,361   |
+| Oster, CDC((https://jamanetwork.com/journals/jama/fullarticle/2788346)) |  71 per million (pfizer)  |  106 per million (pfizer)  |    |   |   56 per million (moderna)  |
+| Mevorach, Israel((https://www.nejm.org/doi/full/10.1056/NEJMoa2109730)) |  -  |   -  |  -  |   1 / 6637  |
-^             Incidence of Myocarditis Following the Second Dose of a Covid-19 mRNA Vaccine                 ^^^^^^^
+A research letter published by JAMA claimed that rates of myocarditis and pericarditis increased less than 100% post-vaccination.((August 4, 2021 | George A. Diaz et al | [[:JAMA]] | Myocarditis and Pericarditis After Vaccination for COVID-19 | [[https://jamanetwork.com/journals/jama/fullarticle/2782900|doi:10.1001/jama.2021.13443]]))
-^  ^  Age 12 - 17  ^  Male Age 12-17  ^  Age 18 - 24  ^  Male Age 18-24  ^  Male Age < 40  ^  Rate from Sars-cov-2  ^
-| Kaiser Permanente Study - Dec 27, 2021((https://www.medrxiv.org/content/10.1101/2021.12.21.21268209v1)) |  1/1860   |  1/2650    |
-| Nature Medicine Paper - Dec 25, 2021((https://www.medrxiv.org/content/10.1101/2021.12.23.21268276v1))|  -  |  -  |  101 excess events per million (Moderna)  |   30 excess events per million  |
-| USA FDA ACIP Meeting Presentation((http://dx.doi.org/10.15585/mmwr.mm7027e2)) |  |  62.8 per million  |   |  50.5 per million  |
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 The CDC continued to recommend use of these vaccinations while urging doctors to follow a list of clinical guidelines and to make VAERS reports as needed. ((https://www.cdc.gov/vaccines/covid-19/clinical-considerations/myocarditis.html))
-In the December 31, 2020 MMWR the CDC released information related to COVID-19 vaccine safety in children aged 5–11 years, covering the November 3–December 19, 2021 period of slightly over a five weeks.  The information was drawn from VEARS and VSAFE and was restricted to those who received Pfizer-BioNTech COVID-19 vaccine. ((https://www.cdc.gov/mmwr/volumes/70/wr/mm705152a1.htm))
+In the December 31, 2021 MMWR the CDC released information related to COVID-19 vaccine safety in children aged 5–11 years, covering the November 3–December 19, 2021 period of slightly over a five weeks.  The information was drawn from VEARS and VSAFE and was restricted to those who received Pfizer-BioNTech COVID-19 vaccine. ((https://www.cdc.gov/mmwr/volumes/70/wr/mm705152a1.htm))
+==== Small Hong Kong Studies ====
+'Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus Vaccine' (Lai, Li et al., 2022)((https://www.acpjournals.org/doi/10.7326/M21-3700))
+"Conclusion: Despite a low absolute risk, there is an increased risk for carditis associated with BNT162b2 vaccination. This elevated risk should be weighed against the benefits of vaccination."
-==== Small Hong Kong Study ====
 'Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination' (Chua, Kwan et al., 2021)((https://pubmed.ncbi.nlm.nih.gov/34849657/))
 "Conclusions: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose."
 ==== Myocarditis Stratified by Age & Sex ====
 Associate Professor Vinay Prasad wrote a Substack piece on December 26, 2021((https://vinayprasadmdmph.substack.com/p/uk-now-reports-myocarditis-stratified?justPublished=true)) that revisits the results of a paper that appeared in Nature Medicine called 'Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection' by Patone, Mei et al..((https://www.nature.com/articles/s41591-021-01630-0.pdf)) His analysis begins with the finding that the incidence of myocarditis in those under 40 years of age is higher post-vaccination than it is is post-Covid infection. It just gets worse from there.
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 [[https://www.sciencedirect.com/science/article/pii/S2352906721000622|Temporal relationship between the second dose of BNT162b2 mRNA Covid-19 vaccine and cardiac involvement in a patient with previous SARS-COV-2 infection ]]
+[[https://jamanetwork.com/journals/jama/fullarticle/2788346|Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021]]
+[[https://www.nejm.org/doi/full/10.1056/NEJMc2116999?query=featured_home|Myocarditis after BNT162b2 Vaccination in Israeli Adolescents]]
+[[https://pubmed.ncbi.nlm.nih.gov/35404496/|Risk of myopericarditis following COVID-19 mRNA vaccination in a large integrated health system: A comparison of completeness and timeliness of two methods]]
 ===== Link dump =====