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--- covid-19_vaccine_trials [2021/12/22 17:04]
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-====== COVID-19 Vaccine Trials ======
-Since mid-2020, **COVID-19 vaccine trials** have taken place around the world for numerous vaccines.
-===== COVID-19 Vaccine Trials by Vaccine Name or Manufacturer =====
-Clean this section up using just the vaccine names.
-==== Moderna Vaccine Trials ====
-[[Moderna]]
-[[https://www.nejm.org/doi/full/10.1056/NEJMoa2035389|Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine]]
-==== Pfizer Vaccine Trials ====
-[[Pfizer]]
-[[https://www.nejm.org/doi/full/10.1056/NEJMoa2034577|Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine]]
-https://market-ticker.org/akcs-www?post=244109
-https://www.nakedcapitalism.com/2021/08/sloppy-pfizer-booster-clinical-trial-consent-form-provides-way-to-exclude-reactions-that-require-emergency-care.html
-=== Major Problems With Pfizer COVID-19 Vaccine Trials ===
-== Nonrandomization of Primary Comorbidity ==
-== Lack of Blinding ==
-Researcher [[David Wiseman]], PhD walks through how Pfizer trials were unblinded, and details the problems associated. https://podcasts.apple.com/us/podcast/ep-989-how-pfizer-completely-fudged-its-safety-and/id1065050908?i=1000541261581
-== Ventevia Whistleblower ==
-Major trial problems were buried for more than a year after a trial observer reported issues to the FDA. https://www.bmj.com/content/375/bmj.n2635?utm_source=twitter&utm_medium=social&utm_term=hootsuite&utm_content=sme&utm_campaign=usage
-==== Sinovac Vaccine Trials ====
-==== AstraZeneca Vaccine Trials ====
-[[https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32661-1/fulltext|Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK]]
-==== CanSinoBIO Vaccine Trials ====
-  * Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial ((Zhu, F.-C., Guan, X.-H., Li, Y.-H., Huang, J.-Y., Jiang, T., Hou, L.-H., Li, J.-X., Yang, B.-F., Wang, L., Wang, W.-J., Wu, S.-P., Wang, Z., Wu, X.-H., Xu, J.-J., Zhang, Z., Jia, S.-Y., Wang, B.-S., Hu, Y., Liu, J.-J., & Zhang, J. (2020). Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet, 396(10249), 479–488. https://doi.org/10.1016/s0140-6736(20)31605-6))
-==== Janssen Vaccine Trials ====
-[[https://www.nejm.org/doi/full/10.1056/NEJMoa2101544|Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19]]
-==== Mix and Match Trials ====
-Trials are ongoing to determine the effectiveness of mixing and matching different COVID-19 vaccine products, such as the [[https://www.campfire.wiki/doku.php?id=MOSAIC|MOSAIC study]] in Canada.
-===== Critiques of COVID-19 Vaccine Trials =====
-These are broad critiques of the vaccine trials. Critiques of specific trials can be found on the individual vaccine trial pages.
-==== Lack of Transparency ====
-[[Aaron Siri]] has documented how the [[FDA]] has actively participated in obscuring data and documents related to COVID-19 vaccine trials.
-https://aaronsiri.substack.com/p/fda-doubles-down-asks-federal-judge?justPublished=true
-==== Trial Manipulation ====
-[[https://eatwellmovewellthinkwell.com/pages/dr-chestnut | Dr. James Chestnut]] takes 15 minutes to [[https://vrevealed.com/c19/numbers-all-lies | critique the structure]] of the Pfizer and Moderna trials.
-==== Rushed Time Scale ====
-Mar 11, 2020 (statnews) Researchers rush into human trials before animal trials complete.
-==== COVID-19 Vaccine Trials and Variants of Interest ====
-[[Mathew Crawford]] has [[https://roundingtheearth.substack.com/p/variant-roulette-evolution-and-immunity|noted the temporal and geographical coincidence]] of vaccine trial sites and emerging [[SARS-CoV-2 variants of interest]].