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-====== COVID-19 Vaccine Adverse Events ======
-The [[adverse events]] associated with the [[COVID-19 vaccines]] are broader and more numerous than for other vaccines, historically.
-===== Quantification of COVID-19 Vaccine Associated Adverse Events =====
-==== AE Reporting Databases ====
-====== COVID-19 Vaccine Adverse Events Research ======
-  * [[COVID-19 Vaccine Adverse Events Research: Mortality]]
-  * [[https://www.mdpi.com/1999-4915/13/10/2056/htm|Jiang, H.; Mei, Y.-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13, 2056. https://doi.org/10.3390/v13102056]]  Authors note, "Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair."
-===== COVID-19 Vaccine Associated Cardiac Injuries =====
-==== Myocarditis ====
-See also: [[covid-19_vaccines:adverse_events:myocarditis|CoVid-19 Vaccine Associated Myocarditis]]
-==== Myopericarditis ====
-See also: [[covid-19_vaccines:adverse_events:myopericarditis|CoVid-19 Vaccine Associated Myopericarditis]]
-Myopericarditis is characterized as inflammation of the pericardium, the membrane surrounding the hear, with involvement of the myocardium.  Symptoms include chest pain, fever, and shortness of breath, and are similar to pericarditis. Involvement of the myocardium is diagnosed though testing for elevated troponin through cardiac imaging.
-==== Pericarditis ====
-See also: [[covid-19_vaccines:adverse_events:pericarditis|CoVid-19 Vaccine Associated Pericarditis]]
-==== Levels of Cardio Biomarkers Post-Vaccination ====
-https://www.thecardiologyadvisor.com/home/topics/acs/acute-coronary-syndrome-acs-biomarkers-mrna-covid19-vaccine/
-===== COVID-19 Vaccine Associated Blood and Vascular Disorders =====
-==== Thrombosis ====
-See also: [[thrombosis|Covid-19 Vaccine Associated Thrombosis]]
-There are three categories of causes of thrombosis: damage to the blood vessel (catheter or surgery), slowed blood flow (immobility), and/or thrombophilia (if the blood itself is more likely to clot).
-==== Thrombocytopenia ====
-See also: [[covid-19_vaccines:adverse_events:thrombocytopenia|Covid-19 Vaccine Associated Thrombocytopenia]]
-==== Cerebral Venous Thrombosis ====
-See also: [[covid-19_vaccines:adverse_events:cerebral_venous_thrombosis|Covid-19 Vaccine Associated Cerebral Venous Thrombosis]]
-Cerebral Venous Thrombosis is a type of stroke in which the venous channels of the brain become thrombosed, resulting in cerebral infarction in the areas corresponding to the thrombosis.
-==== Hemorrhage (Cerebral, Lobar, Acral and Retinal) ====
-See also: [[covid-19_vaccines:adverse_events:stroke|Covid-19 Vaccine Associated Stroke]]
-==== Stroke ====
-See also: [[covid-19_vaccines:adverse_events:stroke|Covid-19 Vaccine Associated Stroke]]
-=== Intracerebral Hemorrhage ===
-See also: [[covid-19_vaccines:adverse_events:stroke:intracerebral_hemorrhage|Covid-19 Vaccine Associated Intracerebral Hemorrhage]]
-==== Vasculitis, including Microscopic Polyangiitis ====
-See also: [[covid-19_vaccines:adverse_events:vasculitis|Covid-19 Vaccine Associated Vasculitis]]
-Vasculitis is an inflammation of the blood vessels that causes changes in the blood vessel walls. When your blood vessel becomes weak, it might stretch and bulge (called an aneurysm). It might also burst open, causing bleeding. This can be life-threatening.
-Microscopic polyangiitis (MPA) is a a rare type of vasculitis, causing inflammation of the small blood vessels. The disease can damage the blood vessels, nervous system and organs. The FIVE most common clinical manifestations of MPA are: kidney inflammation, weight loss, skin lesions, nerve damage, and fevers.
-===== COVID-19 Vaccine Associated Neurological Disorders =====
-==== Guillain-Barré Syndrome ====
-See also: [[covid-19_vaccines:adverse_events:guillain-barré|CoVid-19 Vaccine Associated Guillain-Barré]]
-Guillain-Barré is a neurological disorder in which the body's immune system mistakenly attacks part of its peripheral nervous system—the network of nerves located outside of the brain and spinal cord. GBS can range from a very mild case with brief weakness to nearly devastating paralysis, leaving the person unable to breathe independently. Fortunately, most people eventually recover from even the most severe cases of GBS. After recovery, some people will continue to have some degree of weakness.
-==== Bell’s Palsy, Facial Paralysis & Facial Palsy ====
-See also:  [[covid-19_vaccines:adverse_events:bell’s_palsy|CoVid-19 Vaccine Associated Facial and Bell’s Palsy]]
-==== Myelitis, including Transverse Myelitis  ====
-See also:  [[covid-19_vaccines:adverse_events:myelitis|CoVid-19 Vaccine Associated Myelitis, including Transverse Myelitis]]
-==== Generalized Neurological Complications ====
-See also:  [[covid-19_vaccines:adverse_events:generalized_CNS_events|CoVid-19 Vaccine Associated Generalized Neurological Complications]]
-===== COVID-19 Vaccine Associated Fertility-Related AEs =====
-===== COVID-19 Vaccine Associated Disorders of the Immune System =====
-==== Anaphylaxis ====
-See also: [[covid-19_vaccines:adverse_events:Anaphylaxis|Covid-19 Vaccine Associated Anaphylaxis]]
-Anaphylaxis is a severe life-threatening allergic reaction, resulting from the immune system's response to a substance.
-==== Allergic Reactions (other than and including Anaphylaxis) ====
-[[covid-19_vaccines:adverse_events:allergic_reactions|Covid-19 Vaccine Associated Allergic Reactions]]
-While anaphylaxis is a severe allergic reaction, other allergies can result from or be exasperated by vaccination.
-==== Lymphadenopathy ====
-See also:  [[covid-19_vaccines:adverse_events:lymphadenopathy|CoVid-19 Vaccine Associated Lymphadenopathy]]
-Lymphadenopathy is swelling of the lymph nodes.  These swollen nodes can feel like hard nodules that are sometimes painful and are found in the underarm, groin, neck, chest, and abdomen.  The lymph nodes filter lymph fluid as it circulates through the body.
-=== Axillary Adenopathy ===
-Axillary adenopathy is a lymphadenopathy of the axilla, or underarm.
-See also:  [[covid-19_vaccines:adverse_events:lymphadenopathy:axillary_adenopathy|CoVid-19 Vaccine Associated Axillary Adenopathy]]
-==== COVID-19 Vaccine Associated Inflammation ====
-===== COVID-19 Vaccine Associated Hepatitis =====
-==== Immune-mediated Hepatitis ====
-See also: [[covid-19_vaccines:adverse_events:hepatitis|Covid-19 Vaccine Associated Hepatitis]]
-==== Levels of Inflammatory Biomarkers Post-Vaccination ====
-https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.10712
-===== COVID-19 Vaccine Associated Previously Rare Diseases =====
-===Eosinophilic Granulomatosis with Polyangiitis===
-[[https://academic.oup.com/qjmed/advance-article/doi/10.1093/qjmed/hcab273/6413650#316486976|Eosinophilic granulomatosis with polyangiitis (EGPA) has been associated with CoVid Vaccination]].  EGPA (formerly Churg-Strauss Syndrome) is an extremely rare disease caused by inflammation of blood and/or tissue cells, which previously was known to effect only two to five new people a year per one million people. [[https://nypost.com/2021/12/27/trailer-park-boys-star-candy-palmater-dies-suddenly-at-53/|Candy Palater, star of Trailer Park Boys, died]] after being hospitalized and diagnosed with eosinophilic granulomatosis with polyangiitis.